Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,111-2,120 of 2,298 results
J Comp Neurol, 2002 • February 11, 2002
This study quantitatively assesses the remyelination potential of transplanted Schwann cells in demyelinated rat spinal cords, considering factors like donor age and cell preparation. The research dem...
KEY FINDING: Schwann cells, regardless of donor age or preparation method, can induce remyelination in spinal cord lesions.
PNAS, 2005 • July 26, 2005
The study identifies ephrin-B3, a developmental axon guidance molecule, as a myelin-based inhibitor of neurite outgrowth in the adult spinal cord. Ephrin-B3 is expressed in myelinating oligodendrocyte...
KEY FINDING: Ephrin-B3 is expressed in postnatal myelinating oligodendrocytes in the mouse spinal cord, suggesting a role in myelin-based inhibition of axon outgrowth.
FASEB J., 2004 • February 1, 2004
This study demonstrates the potential of xenotransplantation of characterized OECs into the primate spinal cord, resulting in remyelination of demyelinated axons. The use of HT transgenic pig OECs, mo...
KEY FINDING: Transplantation of HT transgenic pig OECs into demyelinated lesions in the monkey spinal cord resulted in robust remyelination in 62.5% of transplant sites.
PNAS, 2003 • July 22, 2003
This study investigates the impact of glial fibrillary acidic protein (GFAP) and vimentin deficiency on axonal plasticity and functional recovery following spinal cord injury (SCI) in mice. The key fi...
KEY FINDING: Double mutant mice (lacking both GFAP and Vimentin) exhibited significant recovery of locomotor function 5 weeks after spinal cord hemisection.
The Journal of Neuroscience, 2004 • January 14, 2004
This study examined the role of p75NTR in spinal cord regeneration using p75NTR-deficient mice and a p75NTR-Fc fusion molecule. The results showed that neither the deletion of p75NTR nor the administr...
KEY FINDING: p75NTR immunoreactivity was observed in the dorsal horn and medial part of the dorsal column, but not in the CST of normal mice.
The Journal of Neuroscience, 2004 • March 24, 2004
The study reveals that DCC, a netrin-1 receptor, is present both on the neuronal surface and in intracellular pools in embryonic rat spinal commissural neurons. Netrin-1 application leads to a modest ...
KEY FINDING: Netrin-1 modestly increases cell surface DCC without activating PKA, suggesting a PKA-independent mechanism.
CMLS, Cell. Mol. Life Sci., 2004 • January 19, 2004
This study investigates the mechanisms by which olfactory ensheathing cells (OECs) promote axonal regeneration using an in vitro model of axonal injury. The findings indicate that OECs promote neurite...
KEY FINDING: OECs promote neurite sprouting after injury by acting as a physical substrate for growth.
The Journal of Neuroscience, 2004 • July 14, 2004
This study demonstrates that a combinatorial approach, using cAMP to stimulate neuronal cell bodies and neurotrophin-3 (NT-3) to stimulate injured axons, can promote axonal regeneration beyond spinal ...
KEY FINDING: Combined delivery of cAMP and NT-3 significantly promoted axonal growth beyond the spinal cord lesion site, more so than either treatment alone.
The Journal of Neuroscience, 2004 • July 21, 2004
The study developed an in vitro assay that mimics the PG gradient phenotype in the glial scar, demonstrating that adult DRGs form dystrophic endings morphologically and behaviorally similar to those i...
KEY FINDING: PGs can lead to growth cone dystrophy and that, surprisingly, supposedly sterile dystrophic endings are extraordinarily dynamic.
Phil. Trans. R. Soc. Lond. B, 2004 • April 8, 2004
This study investigates the cellular and molecular mechanisms of regeneration in Xenopus tadpoles using transgenic methods and embryonic grafting. Key findings indicate that tail regeneration occurs w...
KEY FINDING: During tail regeneration in Xenopus tadpoles, there is no evidence of de-differentiation or metaplasia; instead, tissues regenerate from their corresponding tissues in the stump.