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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Regenerative Medicine Research

Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.

Showing 2,111-2,120 of 2,298 results

Regenerative MedicineNeurology

A Quantitative Morphometric Analysis of Rat Spinal Cord Remyelination Following Transplantation of Allogenic Schwann Cells

J Comp Neurol, 2002 • February 11, 2002

This study quantitatively assesses the remyelination potential of transplanted Schwann cells in demyelinated rat spinal cords, considering factors like donor age and cell preparation. The research dem...

KEY FINDING: Schwann cells, regardless of donor age or preparation method, can induce remyelination in spinal cord lesions.

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Spinal Cord InjuryRegenerative MedicineNeurology

Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth

PNAS, 2005 • July 26, 2005

The study identifies ephrin-B3, a developmental axon guidance molecule, as a myelin-based inhibitor of neurite outgrowth in the adult spinal cord. Ephrin-B3 is expressed in myelinating oligodendrocyte...

KEY FINDING: Ephrin-B3 is expressed in postnatal myelinating oligodendrocytes in the mouse spinal cord, suggesting a role in myelin-based inhibition of axon outgrowth.

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Regenerative MedicineNeurology

Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells

FASEB J., 2004 • February 1, 2004

This study demonstrates the potential of xenotransplantation of characterized OECs into the primate spinal cord, resulting in remyelination of demyelinated axons. The use of HT transgenic pig OECs, mo...

KEY FINDING: Transplantation of HT transgenic pig OECs into demyelinated lesions in the monkey spinal cord resulted in robust remyelination in 62.5% of transplant sites.

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Spinal Cord InjuryRegenerative MedicineNeurology

Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes

PNAS, 2003 • July 22, 2003

This study investigates the impact of glial fibrillary acidic protein (GFAP) and vimentin deficiency on axonal plasticity and functional recovery following spinal cord injury (SCI) in mice. The key fi...

KEY FINDING: Double mutant mice (lacking both GFAP and Vimentin) exhibited significant recovery of locomotor function 5 weeks after spinal cord hemisection.

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Spinal Cord InjuryRegenerative MedicineNeurology

Suppression of p75NTR Does Not Promote Regeneration of Injured Spinal Cord in Mice

The Journal of Neuroscience, 2004 • January 14, 2004

This study examined the role of p75NTR in spinal cord regeneration using p75NTR-deficient mice and a p75NTR-Fc fusion molecule. The results showed that neither the deletion of p75NTR nor the administr...

KEY FINDING: p75NTR immunoreactivity was observed in the dorsal horn and medial part of the dorsal column, but not in the CST of normal mice.

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Regenerative MedicineNeurologyGenetics

Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension

The Journal of Neuroscience, 2004 • March 24, 2004

The study reveals that DCC, a netrin-1 receptor, is present both on the neuronal surface and in intracellular pools in embryonic rat spinal commissural neurons. Netrin-1 application leads to a modest ...

KEY FINDING: Netrin-1 modestly increases cell surface DCC without activating PKA, suggesting a PKA-independent mechanism.

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Regenerative MedicineNeurologyGenetics

Olfactory ensheathing cells promote neurite sprouting of injured axons in vitro by direct cellular contact and secretion of soluble factors

CMLS, Cell. Mol. Life Sci., 2004 • January 19, 2004

This study investigates the mechanisms by which olfactory ensheathing cells (OECs) promote axonal regeneration using an in vitro model of axonal injury. The findings indicate that OECs promote neurite...

KEY FINDING: OECs promote neurite sprouting after injury by acting as a physical substrate for growth.

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Spinal Cord InjuryRegenerative MedicineNeurology

Combinatorial Therapy with Neurotrophins and cAMP Promotes Axonal Regeneration beyond Sites of Spinal Cord Injury

The Journal of Neuroscience, 2004 • July 14, 2004

This study demonstrates that a combinatorial approach, using cAMP to stimulate neuronal cell bodies and neurotrophin-3 (NT-3) to stimulate injured axons, can promote axonal regeneration beyond spinal ...

KEY FINDING: Combined delivery of cAMP and NT-3 significantly promoted axonal growth beyond the spinal cord lesion site, more so than either treatment alone.

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Spinal Cord InjuryRegenerative MedicineNeurology

Studies on the Development and Behavior of the Dystrophic Growth Cone, the Hallmark of Regeneration Failure, in an In Vitro Model of the Glial Scar and after Spinal Cord Injury

The Journal of Neuroscience, 2004 • July 21, 2004

The study developed an in vitro assay that mimics the PG gradient phenotype in the glial scar, demonstrating that adult DRGs form dystrophic endings morphologically and behaviorally similar to those i...

KEY FINDING: PGs can lead to growth cone dystrophy and that, surprisingly, supposedly sterile dystrophic endings are extraordinarily dynamic.

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Regenerative MedicineGenetics

Cellular and molecular mechanisms of regeneration in Xenopus

Phil. Trans. R. Soc. Lond. B, 2004 • April 8, 2004

This study investigates the cellular and molecular mechanisms of regeneration in Xenopus tadpoles using transgenic methods and embryonic grafting. Key findings indicate that tail regeneration occurs w...

KEY FINDING: During tail regeneration in Xenopus tadpoles, there is no evidence of de-differentiation or metaplasia; instead, tissues regenerate from their corresponding tissues in the stump.

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