Regenerative Medicine Research

KEY FINDING: Substantial protein differences were identified in the early stages of NSC differentiation. More than a third of all the proteins were regulated, including known neuronal and NSC multipotency markers.

KEY FINDING: Systemic administration of FGF21 significantly promoted the functional recovery of SCI in rats, as assessed by BBB scale and inclined plane test.

KEY FINDING: Pro-regenerative zebrafish glia activate an epithelial-to-mesenchymal transition (EMT) gene program, distinguishing them from mammalian glia.

KEY FINDING: A specific SCI-induced cell population, SrRCs, involved in neuronal regeneration.

KEY FINDING: WIT-induced IRI in muscle requests increased numbers of injected MPC to engraft and persist, suggesting a possible rational for cell therapy to antagonize IRI.

KEY FINDING: AAV2-5HRE-bFGF-NSCs treatment yielded temporally increased expression of bFGF in SCI.

KEY FINDING: Identified a new set of coding genes and lncRNAs involved in early neuronal differentiation and validated with functional assays in vitro and in vivo.

KEY FINDING: ahMNCs from patients with hemorrhagic stroke exhibit neural stem cell characteristics and can differentiate into various neural cell lineages.

KEY FINDING: 7, 8-DHF promotes the proliferation, survival, and Schwann-like cell differentiation of BMSCs in vitro by upregulating TrkB and ERK1/2 phosphorylation.

KEY FINDING: Transgenic pig OECs or Schwann cells transplantation restored impulse conduction across and beyond the lesion site in transected rat spinal cords.