Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,061-2,070 of 2,298 results
Neural Plasticity, 2020 • September 25, 2020
This review discusses the potential of combining acupuncture with mesenchymal stem cell (MSC) transplantation as a novel strategy for treating spinal cord injury (SCI). Acupuncture alone has shown eff...
KEY FINDING: Acupuncture improves sensory and motor function in SCI patients by improving activity of daily living (ADL). Pooled analyses in a meta-analysis showed that acupuncture had a beneficial effect on neurological recovery (relative risk: 1.28, 95% confidence interval (CI): 1.12-1.50), motor function (weighted mean difference: 6.86, 95% CI: 0.41-13.31), and functional recovery (standardized mean difference: 0.88, 95% CI: 0.56-1.21).
Neural Regeneration Research, 2021 • April 1, 2021
Human stem cell grafts offer promise for treating central nervous system (CNS) conditions, potentially enabling patient-specific therapies for diseases and injuries. Structured, tissue-based transplan...
KEY FINDING: Human ESC-derived cells transplanted into rodent models have shown success, with ESC-derived axons detected along host white matter tracts and grafted neurons displaying action potentials.
International Journal of Molecular Sciences, 2020 • October 13, 2020
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. The review aims to promote the understanding of SCI pathophys...
KEY FINDING: SCI pathophysiology includes acute and chronic phases with destructive events like ischemia, oxidative stress, inflammation, and apoptosis. Many therapeutic strategies have been proposed.
Neurotherapeutics, 2021 • October 16, 2020
This study investigates the neuroprotective ability of systemic administration of AMP cells on clinical disease progression and histopathology of optic neuritis and myelitis in EAE mice. The results d...
KEY FINDING: Systemic administration of AMP cells significantly reduced ascending paralysis in EAE mice.
Nat Immunol, 2020 • December 1, 2020
The study identifies a novel myeloid cell phenotype with neuroprotective and axonogenic properties that arises in the setting of optic nerve and spinal cord injury. This reparative cell is a CD14+Ly6G...
KEY FINDING: A unique granulocyte subset, characterized as an immature neutrophil, exhibits neuroprotective properties and drives CNS axon regeneration in vivo.
Frontiers in Cellular Neuroscience, 2020 • October 6, 2020
This corrigendum rectifies the omission of a relevant citation in a prior publication concerning the dual role of glial scars and scar-forming astrocytes in spinal cord injury. Specifically, a referen...
KEY FINDING: The original article lacked a citation to Silver (2016) regarding the role of astrocytes in forming a 'drawbridge' for axonal regrowth.
International Journal of Molecular Sciences, 2020 • October 30, 2020
This review focuses on the mechanisms that regulate CNS regeneration, highlighting the history, recent efforts, and questions left unanswered in this field. It has been widely accepted that both extrins...
KEY FINDING: Preventing extrinsic inhibitory signals like chondroitin sulfate proteoglycans (CSPGs) and myelin-associated glycoprotein (MAG) has been one of the promising approaches to promote axon regeneration.
Molecular Medicine Reports, 2020 • July 6, 2020
This study investigates the potential of using neural stem cells (NSCs) preconditioned with high mobility group box-1 (HMGB1) to improve functional recovery after spinal cord injury (SCI) in rats. The...
KEY FINDING: Transplantation of NSCs preconditioned with 1 ng/ml HMGB1 facilitated functional improvement of injured spinal cords, as indicated by improved Basso, Beattie and Bresnahan mean scores, reduced mechanical hypersensitivity, and decreased cold stimulation response.
Stem Cells International, 2020 • October 30, 2020
This study investigated the potential of combining platelet-rich plasma (PRP) gel with bioengineered human embryonic stem cells (hESCs) to treat dorsal rhizotomy (DRZ) in rats. The researchers found t...
KEY FINDING: The combination of hESCs with PRP gel promoted substantial and prominent axonal regeneration processes after DRZ.
Heliyon, 2020 • October 29, 2020
This study investigates the function of the major vault protein (MVP) during organ regeneration using a mvp knockout zebrafish line. The results indicate that the regenerative capacities of the heart, ...
KEY FINDING: The regenerative capacity of the heart, spinal cord, and fins is preserved in mvp knockout zebrafish.