Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 2,021-2,030 of 2,298 results
STEM CELLS AND DEVELOPMENT, 2020 • May 20, 2020
This letter to the editor critically assesses a published study on the use of bone marrow mesenchymal stem cell-derived exosomes (ExoFlo) for treating severe COVID-19. The authors express concerns reg...
KEY FINDING: The letter identifies a lack of information regarding the characterization, biological properties, and therapeutic actions of the ExoFlo product used in the original study.
Stem Cell Research & Therapy, 2020 • June 8, 2020
This study demonstrates the ability of skeletal muscle-derived MPCs to differentiate into smooth muscle cells (MPC-SMCs) with a stable phenotype in vitro. The engraftment of in vitro-differentiated mu...
KEY FINDING: MPC derived from human skeletal muscle can be differentiated into smooth muscle cells (MPC-SMC) in vitro.
COMMUNICATIONS BIOLOGY, 2020 • June 12, 2020
This approach revealed that the M-axon can regenerate very rapidly and that essential functions of the behavior driven by this neuron are fully recovered in just days. As we report here, the regenerat...
KEY FINDING: Mauthner (M-) axon might regenerate better when the spinal cord is injured closer to the soma of the M-cell.
Brain, 2020 • June 1, 2020
This commentary discusses a study that investigated the use of a Nogo receptor decoy (AXER-204) to promote recovery after spinal cord injury in non-human primates. The study found that AXER-204 was sa...
KEY FINDING: AXER-204 showed no toxicity in rodents or primates.
Stem Cell Reports, 2020 • July 14, 2020
The study investigates cell transplantation for SCI in chronic settings, using skin-derived precursors differentiated into Schwann cells (SKP-SCs) in rats 8 weeks post-injury. SKP-SCs survived transpl...
KEY FINDING: SKP-SCs survived long-term at the site of chronic SCI, integrated into the host spinal cord, and mitigated astroglial scar formation.
Exp Cell Res, 2020 • September 15, 2020
This study used single-cell transcript sequencing to identify gene expression markers for specific immune cell types, including erythrocytes, neutrophils, macrophages, and lymphocytes, in axolotl bloo...
KEY FINDING: Six cell populations were identified from peripheral leukocytes presenting gene expression patterns indicative of erythrocyte, thrombocyte, neutrophil, B-cell, T-cell, and myeloid cell populations.
Cerebral Cortex, 2020 • November 1, 2020
This study investigates the role of semaphorins in axon repulsion after spinal cord injury (SCI), identifying that the expression of multiple semaphorin family members is induced by Olig2. Genetic evi...
KEY FINDING: Expression of multiple semaphorin family members (Sema3a, Sema3b, Sema3c, Sema3d, Sema3g, Sema4c, Sema4d, Sema5a, Sema6a, and Sema6d) was elevated one week post-injury in mice.
Cell Tissue Bank, 2020 • June 25, 2020
COVID-19, characterized by severe acute respiratory infections (ARIs), poses a significant global health challenge, with no specific treatment available to date beyond symptom relief. The excessive im...
KEY FINDING: MSCs can regulate the proliferation and activation of immune cells and differentiate into type II alveolar epithelial cells, which are crucial for lung function.
npj Regenerative Medicine, 2020 • January 1, 2020
This study investigates the use of porous collagen-based scaffolds (PCSs) for delivering neural stem cells (NSCs) to spinal cord injury (SCI) sites to promote regeneration. The findings show that PCS ...
KEY FINDING: Porous collagen scaffolds (PCS) seeded with NSCs significantly improved locomotion recovery in mice with dorsal column crush SCI, with performance approaching that of uninjured animals after 12 weeks.
STEM CELLS Transl Med., 2020 • September 1, 2020
This study investigates the neurotrophic effects of decellularized skeletal muscles using a 3D organotypic culture system. The findings demonstrate that decellularized muscle scaffolds attract and sup...
KEY FINDING: Decellularized muscles retain structural proteins of the ECM of both skeletal muscle and peripheral nervous system.