Regenerative Medicine Research

KEY FINDING: In vivo neural reprogramming has achieved impressive progress, ranging from generation of diverse glia-converted neurons in multiple CNS regions to functional improvements for certain neurological conditions.

KEY FINDING: Gene therapy has gained promising advancement in the past decade, as six therapies have gained clinical approval for conditions such as spinal muscular atrophy or Leber’s congenital amaurosis.

KEY FINDING: Conditioned medium from bone marrow-derived MSCs (BMSCs) promotes neural stem cell differentiation into neurons and neurite outgrowth by inhibiting the BMP/Smad signaling pathway.

KEY FINDING: MSC-EVs do not necessarily suppress immune responses, but rather modulate them, specifically moderating acute immune responses toward regulatory responses, inducing tolerance, and restoring homeostasis.

KEY FINDING: Direct administration of autologous ADSCs into the damaged spinal cord area led to significant neurological and motor improvements in a ferret patient with chronic SCI.

KEY FINDING: Manipulating signaling pathways and nuclear transcription factors can effectively drive CNS axon regrowth.

KEY FINDING: Higher serum levels of IL-4 and IL-10 are associated with a better prognosis in SCI, suggesting they could be potential biomarkers.

KEY FINDING: Photobiomodulation enhances tissue repair by modulating cell behavior, promoting cell proliferation, and enhancing stem cell differentiation.

KEY FINDING: GFs-HP hydrogel promotes motor functional recovery after SCI, as shown by footprint analysis and BBB locomotion scores.

KEY FINDING: DMF treatment at 15 mg/kg preserved motoneurons and synapses and decreased astrogliosis and microglial reactions, downregulating pro-inflammatory gene transcripts.