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  4. Reinnervation of spinal cord anterior horn cells after median nerve repair using transposition with other nerves

Reinnervation of spinal cord anterior horn cells after median nerve repair using transposition with other nerves

Neural Regen Res, 2019 · DOI: 10.4103/1673-5374.247474 · Published: April 1, 2019

Regenerative MedicineNeurologySurgery

Simple Explanation

This study investigates nerve regeneration and motor function recovery following different nerve transposition techniques for median nerve defects in rats. The researchers compared epineurial neurorrhaphy with several nerve transposition methods, assessing wrist flexion, nerve fiber characteristics, and muscle recovery. The findings suggest that nerve translocation from different anterior horn motor neurons can effectively repair median nerve injuries and restore some motor function.

Study Duration
3 Months
Participants
30 Sprague-Dawley rats
Evidence Level
Level 3; Animal study

Key Findings

  • 1
    Wrist flexion function was restored in all three nerve transposition groups and the epineurial neurorrhaphy group.
  • 2
    The magnification of proximal to distal nerves was 1.80, 3.00, 2.50, and 3.12 in epineurial neurorrhaphy group, musculocutaneous nerve transposition group, medial pectoral nerve transposition group, and radial nerve muscular branch transposition group, respectively.
  • 3
    Donor nerve translocation from different anterior horn motor neurons can effectively repair the target organs innervated by the median nerve.

Research Summary

The study aimed to observe the effect of nerve regeneration and motor function recovery after several types of nerve transposition for median nerve defect. Results showed that wrist flexion function was restored, and the nerve grew into the distal effector in all three nerve transposition groups and the epineurial neurorrhaphy group. The findings indicate that donor nerve translocation from different anterior horn motor neurons can effectively repair the target organs innervated by the median nerve.

Practical Implications

Clinical Application

Nerve transposition repair can be used to repair severe peripheral nerve injury.

Functional Reinnervation

Spinal anterior horn motor neurons obtain functional reinnervation and achieve some degree of motor function in the affected limbs.

Surgical Technique

The small gap sleeve technique reserves a clear space for nerve regeneration between nerve stumps, reduces the nerve mismatch rate during nerve regeneration and improves the efficacy of median nerve injury

Study Limitations

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