Inhibition of KLF7-Targeting MicroRNA 146b Promotes Sciatic Nerve Regeneration

This study investigates the role of miR-146b, a microRNA, in nerve regeneration following sciatic nerve injury. They found that inhibiting miR-146b promotes the regeneration of nerve cells. The researchers discovered that miR-146b directly targets and suppresses KLF7, a transcription factor important for Schwann cell proliferation and axonal regeneration. By inhibiting miR-146b, the study enhanced the expression of KLF7 and its target genes, leading to improved nerve conduction and regeneration.

• 1
  miR-146b directly targets KLF7 by binding to its 3'UTR, suppressing its expression.
• 2
  Inhibition of miR-146b increased KLF7 expression and promoted axonal outgrowth in a sciatic nerve injury model.
• 3
  Silencing miR-146b enhances Schwann cell proliferation and migration, crucial for nerve regeneration.