Cell Journal, 2018 · DOI: 10.22074/cellj.2018.4777 · Published: April 1, 2018
This study explores a new cell-based therapy for multiple sclerosis (MS) using a combination of neurotrophic factor-secreting cells (NTF-SCs) and human adipose-derived stem cells (hADSCs). The research aims to enhance myelin repair in a rat model of MS, which is characterized by the loss of myelin, a protective sheath around nerve fibers. The experiment involved transplanting these cells into the spinal cords of rats with induced demyelination to evaluate the cells' ability to promote remyelination. The motor functions of the rats were assessed to determine if the cell transplantation improved their condition. The results suggest that co-transplantation of NTF-SCs and hADSCs can improve the remyelination process in the rat model of MS. This approach holds promise as a potential cell-based therapy for neurodegenerative diseases like MS.
Co-transplantation of NTF-SCs and hADSCs offers a potential cell-based therapy for MS by promoting remyelination and improving motor function.
The study suggests that the combined approach enhances the differentiation of stem cells into oligodendrocytes, which are essential for myelin formation.
NTF-SCs serve as a vehicle for delivering neurotrophic factors to the CNS lesions, potentially overcoming limitations of systemic NTF delivery.