Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,381-1,390 of 2,298 results
PNAS, 2024 • September 18, 2024
In this study, we showed that lipin1 orchestrates mechanistic target of rapamycin (mTOR) and STAT3 signaling pathways to determine axon regeneration. Overall, our research reveals that lipin1 function...
KEY FINDING: Lipin1 orchestrates mechanistic target of rapamycin (mTOR) and STAT3 signaling pathways to determine axon regeneration.
Materials Today Bio, 2024 • September 14, 2024
This study developed an injectable adhesive Exo-dECM hydrogel comprising a decellularized extracellular matrix and exosomes derived from cortical neurons as a potential therapeutic intervention for SC...
KEY FINDING: The Exo-dECM hydrogel exhibited robust mechanical stability and excellent cytocompatibility, allowing effective injection into the injury site to fill the lesion cavity.
Archives of Academic Emergency Medicine, 2025 • September 5, 2024
This meta-analysis aimed to investigate the efficacy of mesenchymal stem cell-derived (MSC-derived) exosomes in animal models of spinal cord injuries (SCI). Treatment with MSC-derived exosomes ultimat...
KEY FINDING: Treatment with MSC-derived exosomes improved locomotion and reduced cavity size in animal models of SCI.
Stem Cell Research & Therapy, 2024 • September 18, 2024
Exosomes have attracted significant interest as cell-free therapies owing to their fascinating biological properties. Increasing evidence from preclinical studies has confirmed the neuroprotective pro...
KEY FINDING: Exosomes from mesenchymal stem cells (MSCs) have broad application prospects for SCI and protect neurons through various processes.
Biology, 2024 • September 7, 2024
Axonal regeneration in the spinal cord after traumatic injuries presents a challenge for researchers, primarily due to the nature of adult neurons and the inhibitory environment that obstructs neurona...
KEY FINDING: Inhibiting PTEN promotes axonal regeneration and elongation, emphasizing the significance of PTEN/Akt/mTOR signaling pathway activation, particularly in cerebral cortical neurons.
PNAS, 2015 • May 12, 2015
This study demonstrates that systemic artemin (ARTN) treatment can promote the regeneration of sensory axons to the brainstem after a dorsal root crush injury in adult rats. The regenerated axons rees...
KEY FINDING: Systemic artemin (ARTN) treatment promotes the regeneration of crushed brachial sensory axons to the brainstem within 6 months after dorsal root (DR) crush.
Stem Cell Research & Therapy, 2024 • January 1, 2024
SCI leads to neural impairment, tissue destruction, inflammatory cascades, and imbalances in the nutrient microenvironment. Glial scar formation and insufficient intrinsic mechanisms hinder axonal reg...
KEY FINDING: MSCs interact with immune cells through soluble secretions or direct cell communication to modulate the metabolic activities of inflammatory cells, influencing their function within the inflammatory microenvironment.
Cell Proliferation, 2025 • March 1, 2025
This study investigates the role of KDM2B in promoting neurogenic differentiation of mesenchymal stem cells (MSCs) from dental apical papilla (SCAP) and its impact on nerve injury repair in rats. The ...
KEY FINDING: KDM2B promotes neurogenic differentiation in SCAP cells by enhancing the expression of neurogenic markers and neural sphere formation.
Nature Communications, 2024 • August 16, 2024
This study demonstrates that transplanting human oligodendrocyte progenitor cells (hOPCs), genetically modified to ignore inhibitory signals, improves remyelination in rodent models of multiple sclero...
KEY FINDING: Edited hOPCs showed enhanced migration into SEMA3A-loaded demyelinated lesions compared to control hOPCs.
Clinics, 2024 • January 1, 2024
This study investigates the use of mononuclear stem cells from human umbilical cord and placenta blood to improve motor function in mice with spinal cord injuries in the chronic phase. The results ind...
KEY FINDING: The intervention groups (stem cells) showed statistically significant motor improvement compared to control groups.