Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,341-1,350 of 2,298 results
Nature Communications, 2024 • May 7, 2024
The study investigates adaptive cellular mechanisms in adult zebrafish spinal cord regeneration after traumatic injury, revealing that zebrafish motoneurons are remarkably resilient and remain functiona...
KEY FINDING: Large-size fast spinal zebrafish motoneurons are remarkably resilient by remaining viable and functional after spinal cord injury.
Cells, 2024 • May 10, 2024
Stem cell therapy is a promising strategy for the preservation or restoration of the structure and function of the brain and spinal cord. This review discusses the mechanisms of action of dental and m...
KEY FINDING: DSCs exhibit qualities that make them advantageous to the more intensively investigated MSC neuro-regenerative therapies.
Sci. Adv., 2024 • July 3, 2024
This study introduces a bioinspired hydrogel (HADA/HRR) combined with NT3 and curcumin to enhance tissue integration and neural regeneration following spinal cord injury (SCI). The hydrogel manipulate...
KEY FINDING: HADA/HRR hydrogels can reverse the formation of fibrotic scar after SCI, transforming it into a supportive substrate for regenerating axons.
Cells, 2024 • May 16, 2024
This systematic review investigates how preconditioning mesenchymal stem cells (MSCs) can enhance their therapeutic potential for ischemic and traumatic nervous system injuries. The review encompasses...
KEY FINDING: Preconditioning strategies enhance MSCs' survival and migration by interfering with cellular pathways.
Bioengineering, 2024 • May 6, 2024
This review explores the potential of BMA to modulate inflammatory pathways, enhance tissue regeneration, and restore neurological function disrupted by SCI. The authors hypothesize that BMA’s bioacti...
KEY FINDING: BMA contains mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) that secrete molecules to modulate inflammation, promote angiogenesis, and regenerate damaged neural tissues.
Life, 2024 • May 7, 2024
Urodelean amphibians possess remarkable regenerative abilities, particularly in their tails and spinal cords, a stark contrast to mammals. This regeneration hinges on the capacity of cells to dediffer...
KEY FINDING: Tail and spinal cord regeneration in Urodela involves the restoration of the damaged spinal cord region and extension of the ependymal tube, leading to the formation of new neural cells.
Frontiers in Neurology, 2024 • May 9, 2024
This review summarizes the current understanding of the causes to the poor regeneration within the human CNS and reviews the results of the treatment attempts that have been translated into clinical t...
KEY FINDING: Both intrinsic and extrinsic mechanisms prevent axonal regrowth after CNS injury.
Skeletal Muscle, 2024 • May 13, 2024
The study investigates the impact of mouse strain, sex, and injury type on intramuscular fat (IMAT) formation, myofiber regeneration, and fibrosis. Results show that C57BL/6J mice are resistant to IMA...
KEY FINDING: Bl6 mice are more resistant to IMAT formation compared to 129S and CD1 strains.
Prog Neurobiol, 2024 • August 1, 2024
This study investigates the role of calcium in dendrite injury detection and regeneration using Drosophila da neurons. It demonstrates that dendrite injury induces global calcium influx into the cytos...
KEY FINDING: Dendrite injury triggers a global calcium influx into the cytosol, which is similar to what happens after axon injury.
Front. Cell Dev. Biol., 2024 • May 31, 2024
This review explores the potential of repurposing developmental genes, particularly those involved in embryogenesis and CNS development, for therapeutic induction of axonal and cellular regeneration i...
KEY FINDING: Wnt pathway components may overcome inhibitory conditions following CNS injury and promote axonal regeneration.