Preconditioning of MSCs for Acute Neurological Conditions: From Cellular to Functional Impact—A Systematic Review

Cells, 2024 · DOI: 10.3390/cells13100845 · Published: May 16, 2024

Simple Explanation

This review examines how different pre-conditioning methods affect mesenchymal stem cells (MSCs) and their ability to treat nervous system injuries. The review includes 52 studies that report nine different preconditioning approaches, such as manipulating oxygen levels, using chemicals, or applying physical forces. These preconditioning strategies can improve MSC survival and migration, change their characteristics, and alter the substances they produce, ultimately enhancing their therapeutic potential.

Study Duration

Not specified

Participants

52 preclinical studies in cell cultures or animals

Evidence Level

Systematic Review

Key Findings

1
Preconditioning strategies enhance MSCs' survival and migration by interfering with cellular pathways.
2
Preconditioned MSCs promote tissue regeneration, reduce neuroinflammation, and improve angiogenesis and myelinization in animal models of neurological injuries.
3
The study suggests that combining different preconditioning strategies could further enhance the therapeutic effects of MSCs.

Research Summary

This systematic review investigates how preconditioning mesenchymal stem cells (MSCs) can enhance their therapeutic potential for ischemic and traumatic nervous system injuries. The review encompasses 52 studies, revealing that preconditioning strategies influence MSCs' survival, migration, phenotype, and secretion of various factors. Overall, the review concludes that preconditioning strategies can stimulate pathways related to the therapeutic effects of MSCs, suggesting the potential for combined approaches to further improve outcomes.

Practical Implications

Enhancing MSC Therapy

Preconditioning can improve MSC's therapeutic effects, making them more effective for treating neurological conditions.

Combining Strategies

Exploring combinations of preconditioning methods may lead to even greater therapeutic benefits.

Addressing Limitations

Preconditioning could potentially solve issues like donor-associated variability in MSC therapy.

Study Limitations

1
Lack of information regarding randomization and blinding of the experimental design.
2
Few studies investigated the combination of different preconditioning strategies.
3
Standardizing treatment approaches (dosage, oxygen pressure) is needed.

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