Regenerative Medicine Research

KEY FINDING: SeNPs@ZIF-8 nanoparticles, particularly medium-sized ones (SSe@ZIF-8), exhibit enhanced ROS scavenging ability compared to SeNPs alone, reducing cytotoxicity.

KEY FINDING: Salidroside enhances functional recovery in SCI mice by promoting axonal regeneration, myelin reconstitution, and inhibiting glial scar formation and the activation of neurotoxic A1 astrocytes.

KEY FINDING: The FTY720-CDs@GelMA hydrogel significantly enhanced NSC proliferation while promoting neuronal regeneration and synaptic formation, thereby reducing cavity area in the injured spinal cord.

KEY FINDING: Increased plasma lycopene concentrations, higher red meat consumption, and lower poultry consumption were associated with an increased risk for Alzheimer’s disease in individuals with a neurogenesis-centred susceptibility.

KEY FINDING: Exosome treatment consistently increased the BBB score from 1 to 8 weeks compared with the Gelfoam-saline and SCI control groups, indicating improved locomotor function.

KEY FINDING: The co-application of hUC-MSC-sEVs can improve the efficacy of rhBMP-2 to promote the regeneration of osteoporotic bone defects.

KEY FINDING: The study successfully assembled the axolotl genome into 14 chromosomes, covering 27.3 Gb and encompassing 94% of annotated gene models.

KEY FINDING: MgAl-LDH nanoparticles of 100 nm size significantly promote the differentiation of ESCs into NPCs compared to 30 nm and 50 nm sizes.

KEY FINDING: UA treatment led to long-term neuroprotection, decreasing microglial reactions and reactive astrogliosis.

KEY FINDING: The ROS-responsive nanoparticles (ROS Nano@Feb-1) were successfully constructed and can release the drug Feb-1 in response to high ROS levels, which are characteristic of SCI.