Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,321-1,330 of 2,298 results
Front. Neurosci., 2024 • March 6, 2024
Spinal cord injury (SCI) has devastating consequences for the physical and social wellbeing of individuals, affecting more than 250,000 people each year worldwide. Despite progress in preclinical SCI ...
KEY FINDING: Transplantation of neural stem/progenitor cells (NSPCs) can promote regeneration of the injured spinal cord by providing new neurons that can integrate into injured host neural circuitry.
Advanced Science, 2024 • March 22, 2024
The study developed a bifunctional neural stem cell (NSC) delivery system using a temperature-responsive nanohydrogel containing magnetic nanoparticles (MNPs) and methylprednisolone (MP) for spinal co...
KEY FINDING: The delivery system releases MP to reduce inflammation by promoting M2 microglia polarization and inhibiting M1 polarization, reducing neuronal apoptosis.
npj Regenerative Medicine, 2024 • February 6, 2024
This study demonstrates that elevated SHH signaling in hNPCs by inhibiting its negative regulator, SUFU, enhanced cell survival and promoted robust neuronal differentiation with extensive axonal outgr...
KEY FINDING: SUFU inhibition in hNPCs enhances cell survival and promotes robust neuronal differentiation with extensive axonal outgrowth, counteracting the harmful effects of the injured niche.
Biology Open, 2024 • January 1, 2024
This study investigates the role of P2X7 receptors in spinal cord regeneration in zebrafish, focusing on their expression and function in ependymo-radial glia (ERG) cells. The research demonstrates th...
KEY FINDING: A truncated P2X7 receptor variant is expressed in neurons and ependymo-radial glia (ERG) within the adult zebrafish spinal cord.
Tissue Eng Regen Med, 2024 • March 26, 2024
This editorial discusses immunomodulation strategies to enhance nerve recovery after spinal cord injury (SCI). Various therapeutic methods, including stem cell transplantation, cytokine delivery, and ...
KEY FINDING: Stem cells like MSCs and NSCs can release anti-inflammatory cytokines and reduce the migration of inflammatory cells to the injured area, promoting recovery from spinal cord damage.
Biomedicines, 2024 • March 19, 2024
This review explores the potential applications of dental-derived stem cells in SCI neural repair, covering various treatment strategies. Assessing the clinical effectiveness of dental-derived stem ce...
KEY FINDING: Dental-derived stem cells (DPSCs, SHED, SCAP, DFSCs) show potential to differentiate into neural cells and promote SCI repair in animal models.
Tissue Eng Regen Med, 2024 • April 5, 2024
The study investigates cell therapy for syringomyelia using MSCs and iNSCs in a rat model with focal dilatation of the central canal, aiming to reduce cavity size and alleviate neuropathic pain. Resul...
KEY FINDING: Cell transplantation promotes syrinx shrinkage and stimulates ependymal cell proliferation, with effects related to transplantation location; reactions occur only when cells are transplanted into the cavity.
Cell Death and Disease, 2024 • April 8, 2024
This review provides a comprehensive overview of how PTEN regulates the activities of different stem cell populations and influences neurological disorders. PTEN's mechanistic workings involve diverse...
KEY FINDING: PTEN plays a crucial role in stem cell self-renewal, proliferation, differentiation, survival and metabolism.
Frontiers in Molecular Neuroscience, 2024 • April 3, 2024
The study validates nano-pulling's ability to induce axon growth in an in vitro regeneration model using dissected DRG. MNPs are able to penetrate the ganglia and localize inside neuronal cells and wi...
KEY FINDING: Nano-pulling doubles the regeneration rate of axons in DRG explants compared to spontaneous regeneration.
Nanomaterials, 2024 • April 22, 2024
This review explores the potential of α-gal nanoparticles to induce regeneration in adult mice, mimicking the natural regenerative abilities observed in amphibians. The approach focuses on activating ...
KEY FINDING: α-Gal nanoparticles induce rapid and extensive macrophage recruitment in adult mice injuries.