Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 121-130 of 2,298 results
PNAS, 2013 • March 5, 2013
This study used a transgenic mouse model to visualize and quantify spontaneously regenerated myelin after spinal cord injury, distinguishing it from pre-existing myelin. The research challenges the as...
KEY FINDING: OL-regenerated sheaths elongated progressively over 6 mo to approach control values.
Neurotherapeutics, 2013 • February 26, 2013
This study investigates the potential of combined therapy involving surgical re-implantation of avulsed lumbar spinal roots and intraspinal transplantation of mesenchymal stem cells (MSCs) to promote ...
KEY FINDING: Transplantation of MSCs significantly increased the survival of motoneurons after ventral root avulsion, with a 45% survival rate in MSC-treated animals compared to 28% in vehicle-injected rats.
Cell. Mol. Life Sci., 2013 • March 1, 2013
The review analyzes the current understanding of MSCs secretome as a new paradigm for treating CNS neurodegenerative diseases, highlighting their potential to secrete neuroregulatory factors that prom...
KEY FINDING: MSCs secrete factors that increase neurogenesis, inhibit apoptosis and glial scar formation, modulate the immune system, and promote angiogenesis, neuronal and glial cell survival.
BioMed Research International, 2013 • January 1, 2013
This review comprehensively covers publications in the field of cell transplantation for spinal cord injury (SCI) from recent years, focusing on commonly utilized cell lineages. Specific areas covered...
KEY FINDING: ESC/iPSC-derived cells can promote tissue sparing, neuronal regeneration, axonal regeneration/remyelination, sensory function, and motor function improvement in SCI models.
Biomatter, 2011 • October 1, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Interestingly, the novel chondroitin sulfate-binding peptide enhances the contr...
KEY FINDING: PEG gels that contained only C6S (PEG-C6S) had the fastest NGF release, while gels that contained both BP and C6S had the slowest release profile (PEG-BP-C6S).
Neuroscience, 2013 • June 25, 2013
This study investigates the role of ephrin B2, an inhibitory axonal guidance molecule, in the failure of axonal regeneration following spinal cord injury (SCI). Using a conditional knockout mouse mode...
KEY FINDING: Deletion of ephrin B2 in astrocytes reduced astrogliosis and accelerated motor function recovery after spinal cord injury in mice.
Biology Open, 2013 • January 1, 2013
This study demonstrates that optogenetics can be used to initiate regeneration of a complex vertebrate structure in vivo by light-gated H+ pump, Archaerhodopsin. Light-activated Arch activity restores...
KEY FINDING: Light activation of Archaerhodopsin (Arch) hyperpolarizes cells in vivo, rescuing Xenopus embryos from craniofacial and patterning abnormalities.
PLoS ONE, 2013 • March 8, 2013
The study aimed to determine if ARSB, a mammalian enzyme, could improve locomotor function after spinal cord injury in mice, similar to ChaseABC but with potentially better stability and immunogenicit...
KEY FINDING: ARSB is more thermostable than ChaseABC at physiological temperature and acidic pH levels relevant to injured tissue.
The Journal of Neuroscience, 2013 • March 27, 2013
The study demonstrates that a continuous growth-promoting pathway, constructed by grafting Schwann cells overexpressing GDNF within and caudal to a spinal cord injury, leads to anatomical regeneration...
KEY FINDING: Grafted Schwann cells overexpressing GDNF promoted regeneration of descending propriospinal (DPST) axons through and beyond the lesion gap of a spinal cord hemisection.
Neurosci Bull, 2013 • August 1, 2013
After spinal cord injury (SCi), re-establishing functional circuitry in the damaged central nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient intrinsic growth c...
KEY FINDING: Combinatorial therapies with ChABC have shown synergistic effects with cell implantation in enhancing functional recovery after spinal cord injury, improving graft integration and axon regeneration across the lesion.