Cell Transplantation for Spinal Cord Injury: A Systematic Review

Cell transplantation is being explored as a way to treat spinal cord injuries. Researchers are testing different types of cells to see if they can help the spinal cord heal. The review looks at various studies that have examined how well transplanted cells survive, help with nerve regeneration, and improve function after spinal cord injury. Despite progress, there is still a gap between lab research and actual treatments for patients. This article reviews what has been published in the field in recent years.

• 1
  ESC/iPSC-derived cells can promote tissue sparing, neuronal regeneration, axonal regeneration/remyelination, sensory function, and motor function improvement in SCI models.
• 2
  MSCs can regulate post-SCI inflammatory response and have neurotrophic paracrine activity, which can lead to improved sensorimotor function.
• 3
  OECs have potential in promoting neuronal regeneration and supporting axonal outgrowth after SCI, but the exact mechanisms are still not fully understood and results vary depending on several factors.