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  4. Photobiomodulation Therapy and Cell Therapy Improved Parkinson’s Diseases by Neuro-regeneration and Tremor Inhibition

Photobiomodulation Therapy and Cell Therapy Improved Parkinson’s Diseases by Neuro-regeneration and Tremor Inhibition

J Lasers Med Sci, 2022 · DOI: 10.34172/jlms.2022.28 · Published: June 23, 2022

Regenerative MedicineNeurologyRehabilitation

Simple Explanation

Parkinson’s disease (PD) is a neurodegenerative disorder affecting the central nervous system, characterized by cell reduction in the substantia nigra and α-synuclein accumulation. Besides drug treatment, therapies like surgery, cell therapy, and laser therapy can be explored. This review evaluates the potential of cell therapy and laser therapy in PD for improving motor function, cell differentiation, and dopaminergic cell proliferation.

Study Duration
Not specified
Participants
Not specified
Evidence Level
Review Article

Key Findings

  • 1
    Cell therapy, particularly using mesenchymal stem cells (MSCs), shows promise due to their self-renewal, differentiation, and immunomodulatory properties.
  • 2
    Photobiomodulation (PBM) therapy can reduce oxidative stress, increase growth factors, promote cell proliferation, and reduce inflammation.
  • 3
    Combining cell therapy and photobiomodulation may enhance the treatment of PD symptoms.

Research Summary

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and accumulation of α-synuclein. Cell therapy, especially with MSCs, offers neuroprotection and immunomodulation, improving motor defects and dopaminergic neuron survival. Photobiomodulation therapy reduces oxidative stress and inflammation, enhancing nerve function and motor skills in PD patients.

Practical Implications

Stem Cell Therapy Potential

MSCs from various sources (umbilical cord, adipose tissue, bone marrow) can be used to improve motor function and neuronal survival in PD models.

Photobiomodulation Benefits

PBM can be applied transcranially or intracranially to reduce inflammation, promote neuroprotection, and enhance motor skills in PD patients.

Combined Therapeutic Approach

Combining cell therapy and photobiomodulation may offer synergistic benefits for treating PD symptoms.

Study Limitations

  • 1
    Potential tumorigenesis with iPS-derived cells
  • 2
    Blood-brain barrier limits MSC transport
  • 3
    Variability in treatment response

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