Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 1,171-1,180 of 2,298 results
Int. J. Mol. Sci., 2023 • February 14, 2023
This study aimed to induce hWJ-MSCs into neural stem/progenitor cells in sphere formation (neurospheres) by using neurogenesis-enhancing small molecules (P7C3 and Isx9) and transplant to recover an SC...
KEY FINDING: Neurospheres induced by 10 µM Isx9 for 7 days produced neural stem/progenitor cell markers such as Nestin and β-tubulin 3 through the Wnt3A signaling pathway regulation markers (β-catenin and NeuroD1 gene expression).
World Journal of Orthopedics, 2023 • February 18, 2023
The study investigates the effects of human neural stem cells-secretome (HNSCs-secretome) on spinal cord injury (SCI) regeneration in a rat model. Results indicate that HNSCs-secretome improves locomo...
KEY FINDING: HNSCs-secretome significantly improved locomotor recovery, as measured by BBB scores, in rats with SCI.
Cell Prolif., 2023 • September 1, 2023
This study profiles the transcriptomes, nucleosome positioning, and histone modifications of mouse haESC lines, comparing these profiles with those of other closely-related stem cell lines, MII oocyte...
KEY FINDING: haESCs exhibit transcriptome profiles more similar to those of naïve pluripotent stem cells, with repressed Xist indicating no X chromosome inactivation.
Protein Cell, 2023 • February 10, 2023
This review summarizes recent progress in preclinical and clinical strategies for SCI treatment, highlighting challenges and prospects for spinal cord repair. Many preclinical interventions fail to tr...
KEY FINDING: Failure of regeneration after SCI is attributed to the poor intrinsic regrowth capacity of adult neurons and the non-permissive local environment.
Not specified, 2023 • February 21, 2023
This study uses patch-based single-cell RNA sequencing to investigate the transcriptomic profiles of regenerating versus non-regenerating corticospinal tract (CST) neurons following PTEN and SOCS3 del...
KEY FINDING: Mitochondrial activities are heavily involved in CST regeneration, with genes related to ATP metabolism and oxidative phosphorylation being overexpressed in regenerating neurons.
Burns & Trauma, 2023 • January 1, 2023
Inflammation has a complex role in SCI, with early events critical for clearing debris and limiting acute injury severity. Excessive inflammation after acute stages can impair regeneration, but certai...
KEY FINDING: Inflammatory responses after SCI are complex, with both beneficial and detrimental effects.
Materials Today Bio, 2023 • February 11, 2023
This review discusses the design principles of MNs for ISTR and their applications in promoting the repair of damaged tissues such as skin wounds, corneal injuries, myocardial infarction (MI), and end...
KEY FINDING: Microneedles can improve the delivery of active substances to enhance bioavailability in tissue repair.
Journal of Orthopaedic Translation, 2023 • February 6, 2023
This study investigates the therapeutic potential of cerebrospinal fluid-derived extracellular vesicles (CSF-EVs) for spinal cord injury (SCI). The researchers isolated CSF-EVs from pigs with SCI and ...
KEY FINDING: CSF-EVs, especially those derived from pigs with SCI (SCI-EVs), promote vascular regeneration more effectively than those from pigs without SCI (Sham-EVs).
Frontiers in Immunology, 2023 • February 24, 2023
The role of MSCs in the treatment of SCI is promising. MSCs achieve immunosuppression through direct contact with immune cells or paracrine release signalling molecules to reduce the inflammatory respo...
KEY FINDING: MSCs can suppress immunity against inflammation by direct contact with immune cells or paracrine activity, modulating the release of cytokines and growth factors at the injury site.
Journal of Nanobiotechnology, 2023 • March 8, 2023
The study investigates the combined effects of MgFe-LDH/NT3 nanoparticles and ultrasound (US) for treating spinal cord injury (SCI). In vitro, the combined treatment promoted neural stem cell differen...
KEY FINDING: Combined treatment of MgFe-LDH/NT3 nanoparticles and ultrasound promoted neural stem cell differentiation into neurons in vitro.