Pulmonology Research

KEY FINDING: High-dimensionality reduction and spatial clustering (HDR-SC) of MALDI-MSI datasets can accurately identify tissue microanatomy in both healthy and diseased lung tissues.

KEY FINDING: SMIP was found to be the most reliable measure of inspiratory muscle performance, followed by MIP.

KEY FINDING: Activity-based therapies, like intermittent hypoxia, have shown promise in improving respiratory function after spinal cord injuries by amplifying plasticity in damaged respiratory networks.

KEY FINDING: Rapamycin pretreatment significantly reduced lung damage after ASCI, including cell death, inflammatory exudation, hemorrhage, and pulmonary congestion, at 12 and 48 hours post-injury.

KEY FINDING: Respiratory muscle training (RMT) increased maximal inspiratory pressure (PImax) by 32% in the active group.

KEY FINDING: Early and aggressive secretion clearance management, combined with moderate airway pressure release ventilation, can effectively improve oxygenation and promote pulmonary rehabilitation without compromising hemodynamics.

KEY FINDING: The incidence of PE among spinal cord injury patients with VTE symptoms was 6.70%.

KEY FINDING: Pulmonary function was generally worse in participants with SCI compared to the controls.

KEY FINDING: Therapeutic PNS has been demonstrated as feasible and safe in lung-healthy and critically ill patients.

KEY FINDING: Combined oropharyngeal and RMT are feasible for individuals with SCI/D, as evidenced by high recruitment, adherence, and retention rates.