Browse the latest research summaries in the field of pulmonology for spinal cord injury patients and caregivers.
Showing 1-10 of 155 results
Nature, 2011 • July 14, 2011
This study investigates methods to restore respiratory activity after cervical spinal cord injury (SCI) by targeting perineuronal net (PNN) associated chondroitin sulfate proteoglycans (CSPGs) around ...
KEY FINDING: ChABC treatment alone promotes plasticity of spared tracts and restores limited activity to the paralyzed diaphragm.
Exp Neurol, 2012 • May 1, 2012
This review highlights experimental strategies to restore respiratory function after spinal cord injury (SCI), focusing on the innate plasticity and capacity for adaptation in the respiratory system a...
KEY FINDING: Pharmacological treatments, such as theophylline, can partially restore function to the paralyzed hemidiaphragm by increasing respiratory drive.
Trauma Surg Acute Care Open, 2025 • January 1, 2025
This retrospective study evaluated the association between prophylactic iNPPV and the incidence of pneumonia in patients with acute CSCIs. The study included 94 patients diagnosed with CSCIs with ASIA...
KEY FINDING: Prophylactic iNPPV was associated with a lower incidence of pneumonia compared to usual care in patients with acute CSCIs.
BMJ Open Respir Res, 2025 • January 1, 2025
This study reports on 359 adults established on domiciliary MIE. The range of prescribed settings is narrow, reflecting the limited evidence base in this field and the need to better understand optima...
KEY FINDING: The most common diagnostic groups using MIE were congenital neuromuscular disease (26%), spinal cord injury (23%), and amyotrophic lateral sclerosis (23%).
Top Spinal Cord Inj Rehabil, 2024 • January 1, 2024
This study describes the adaptation and implementation of a rehabilitation-led model for managing OSA in an SCI rehabilitation center in Australia, addressing the high prevalence and poor management o...
KEY FINDING: A rehabilitation-led model for managing OSA was successfully adapted and implemented in an Australian SCI rehabilitation center.
Brazilian Journal of Anesthesiology, 2024 • December 25, 2021
The case report describes the use of ultrasound to evaluate diaphragm function in a patient with a C3 spinal cord injury, leading to the detection of diaphragm dysfunction. Based on the ultrasound fin...
KEY FINDING: Ultrasound evaluation revealed diaphragmatic dysfunction in a patient with C3 spinal cord injury.
Neural Regeneration Research, 2023 • February 1, 2023
The study investigates the impact of C2 spinal cord hemisection (C2HS) on respiratory, cardiovascular, and renal functions in rats, revealing that diaphragm activity and systolic function are affected...
KEY FINDING: Global ventilation parameters were not impacted 7 days post-C2 hemisection, suggesting compensation.
Spinal Cord Series and Cases, 2022 • October 12, 2022
This pilot study assessed the adherence to and impact of a home-based high-intensity inspiratory muscle training (IMT) program on individuals with spinal cord injury (SCI). The study found that partic...
KEY FINDING: Participants completed an average of 69% of their training days in the first month of daily IMT, and 65% overall.
Frontiers in Bioengineering and Biotechnology, 2023 • January 12, 2023
This study developed a cost-effective and reliable diaphragm pacing (DP) system using bidirectional constant current stimulation for respiratory assistance. The effectiveness of the developed DP syste...
KEY FINDING: The increase of stimulus frequency and amplitude in animals resulted in different degrees of increase in envoked volume.
Spinal Cord, 2023 • March 17, 2023
This study investigated the feasibility of using mouthpiece ventilation (MPV) for post-extubation breathing support in acute cervical spinal cord injury (CSCI) patients in the ICU. The results indicat...
KEY FINDING: MPV is feasible for post-extubation support in acute CSCI patients in the ICU.