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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Physiology Research

Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.

Showing 311-320 of 321 results

Regenerative MedicinePhysiologyNeurology

The Prenylflavonoid ENDF1 Overrules Central Nervous System Growth Inhibitors and Facilitates Regeneration of DRG Neurons

Frontiers in Cellular Neuroscience, 2019 • July 24, 2019

This study investigates the pro-neuroregenerative activity of ENDF1, a prenylated flavonoid, on dorsal root ganglion (DRG) neurons in the presence of extracellular matrix (ECM) growth inhibitors. The ...

KEY FINDING: ENDF1 promotes neurite regrowth of DRG neurons despite the presence of inhibitory ECM molecules.

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PhysiologyNeurologyGenetics

Functional Integration of Neuronal Precursors in the Adult Murine Piriform Cortex

Cerebral Cortex, 2020 • March 1, 2020

The study examines the functional maturation and integration of neuronal precursors in the adult murine piriform cortex, focusing on whether these precursors become equivalent to neighboring principal...

KEY FINDING: Young complex cells receive less synaptic input and fire action potentials at lower frequencies compared to mature principal neurons, similar to neonatal principal neurons.

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PhysiologyNeurologyPediatrics

Curcumin: Novel Treatment in Neonatal Hypoxic-Ischemic Brain Injury

Frontiers in Physiology, 2019 • November 13, 2019

This study investigated the neuroprotective effects of curcumin in a neonatal mouse model of hypoxic-ischemic (HI) brain injury. The researchers explored different administration times and dosages of ...

KEY FINDING: Curcumin administration prior to HIE in neonatal mice elevated cell and tissue loss, as well as glial activation compared to HI alone.

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Spinal Cord InjuryRegenerative MedicinePhysiology

Spinal Cord Injury: Pathophysiology, Multimolecular Interactions, and Underlying Recovery Mechanisms

International Journal of Molecular Sciences, 2020 • October 13, 2020

Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. The review aims to promote the understanding of SCI pathophys...

KEY FINDING: SCI pathophysiology includes acute and chronic phases with destructive events like ischemia, oxidative stress, inflammation, and apoptosis. Many therapeutic strategies have been proposed.

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PhysiologyNeurology

TMS–EEG Co-Registration in Patients with Mild Cognitive Impairment, Alzheimer’s Disease and Other Dementias: A Systematic Review

Brain Sci., 2021 • February 27, 2021

This systematic review synthesizes findings from studies using TMS–EEG co-registration in patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and other dementias. We aimed to revi...

KEY FINDING: TMS-EEG studies have identified a reduced TMS-evoked P30 response in AD patients, particularly in the temporo-parietal and fronto-central areas, indicating sensorimotor system rearrangement. The authors found in the AD patients a significantly decreased TMS-evoked P30 (time-locked response 30 ms after the TMS) in the temporo-parietal cortex ipsilateral to stimulation side and in the contralateral fronto-central area corresponding to the sensori-motor network

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PhysiologyNeurologyPain Management

Sodium channel expression in the ventral posterolateral nucleus of the thalamus after peripheral nerve injury

Molecular Pain, 2006 • August 17, 2006

This study demonstrates that peripheral nerve injury induces changes in the excitability and sodium channel expression in the VPL nucleus of the thalamus. Specifically, the expression of Nav1.3 sodium...

KEY FINDING: Peripheral nerve injury (CCI) leads to increased firing rates of VPL neurons in response to peripheral stimuli.

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Spinal Cord InjuryRegenerative MedicinePhysiology

Sensory Afferents Regenerated into Dorsal Columns after Spinal Cord Injury Remain in a Chronic Pathophysiological State

Exp Neurol, 2007 • August 1, 2007

The study investigates the physiological properties of regenerated sensory axons in the dorsal columns after spinal cord injury (SCI) in rats. It was found that regenerated axons, six months post-inju...

KEY FINDING: Regenerated axons had reduced conduction velocity compared to intact axons.

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Spinal Cord InjuryRegenerative MedicinePhysiology

Structural differentiation of skeletal muscle fibers in the absence of innervation in humans

PNAS, 2007 • December 4, 2007

This study examined the impact of functional electrical stimulation (FES) on denervated muscles in spinal cord injury patients. The patients underwent FES for 2.4-9.3 years. Results showed significant...

KEY FINDING: FES treatment significantly increased muscle fiber diameter in denervated muscles compared to untreated muscles. The fiber size increase was accompanied by a reduction in connective and adipose tissues.

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Spinal Cord InjuryPhysiologyNeurology

Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantation

J Physiol, 2008 • March 27, 2008

The study investigates the impact of olfactory ensheathing glia (OEG) transplantation on the phenotypic characteristics of fast- and slow-twitch hind limb skeletal muscle in rats with completely trans...

KEY FINDING: OEG transplantation results in hind limb skeletal muscle phenotypes that are generally intermediate between paralyzed and control and different from both.

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Spinal Cord InjuryPhysiologyNeurology

Postnatal conversion of cross phrenic activity from an active to latent state

Exp Neurol, 2009 • September 1, 2009

This study investigates the conversion of crossed phrenic activity from a spontaneously active to latent status during postnatal development in rats. Crossed phrenic activity was spontaneously express...

KEY FINDING: Crossed phrenic activity is spontaneously expressed in all three parts of the ipsilateral hemidiaphragm of P2 rats following C2 hemisection injury.

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