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  4. Limb segment load inhibits post activation depression of soleus H-reflex in humans

Limb segment load inhibits post activation depression of soleus H-reflex in humans

Clin Neurophysiol, 2012 · DOI: 10.1016/j.clinph.2012.02.068 · Published: September 1, 2012

Spinal Cord InjuryPhysiologyRehabilitation

Simple Explanation

This study looked at how limb load impacts spinal reflexes, specifically the H-reflex of the soleus muscle, in healthy individuals and one person with a spinal cord injury. Researchers applied different levels of compressive load to the lower leg and measured the H-reflex response. The main finding was that limb load decreases post-activation depression, a process that normally inhibits reflexes after repeated stimulation.

Study Duration
Not specified
Participants
28 healthy adults and one SCI subject
Evidence Level
Level 2; Experimental Study

Key Findings

  • 1
    Limb segment load decreases post-activation depression of the soleus H-reflex in healthy adults.
  • 2
    The decrease in post-activation depression is related to the magnitude of the applied load (higher load, greater decrease).
  • 3
    In the individual with chronic SCI, the response to limb load was different, suggesting spinal cord reorganization affects how these reflexes are modulated.

Research Summary

This study investigated the effect of limb segment load on soleus H-reflex amplitude and post activation depression in healthy individuals and one individual with chronic SCI. The results showed that limb segment load decreases post-activation depression in humans, with the effect scaling according to the load applied. The findings suggest that the mechanism associated with post activation depression is modulated by limb segment load and may be influenced by spinal reorganization after SCI.

Practical Implications

Rehabilitation Strategies

Mechanical loading may be used to capitalize on neuronal tissue plasticity after spinal cord injury.

Understanding Spasticity

Limb segment load impairs the post activation depression mechanism, which may be associated with spasticity in people with SCI.

Future Research

Further studies are needed to determine if individuals with SCI also show a limb load response.

Study Limitations

  • 1
    The study included only one subject with SCI, limiting the generalizability of those findings.
  • 2
    The specific neuronal mechanisms responsible for the observed effects are not fully understood.
  • 3
    The influence of inter-neuronal networks in response to small changes in background EMG was not fully determined.

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