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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Physiology Research

Browse the latest research summaries in the field of physiology for spinal cord injury patients and caregivers.

Showing 11-20 of 321 results

Spinal Cord InjuryPhysiologyNeurology

Contact heat evoked potentials reveal distinct patterns of spinal cord impairment in degenerative cervical myelopathy beyond MRI lesions

Eur J Neurol, 2025 • January 1, 2025

CHEPs revealed distinct patterns of spinal cord impairment independent of structural T2-­positive lesions, which were associated with measures of cord motion. CHEPs thus provide valuable complementary...

KEY FINDING: Abnormal CHEPs were present in T2-­positive DCM (C6:41%; C8:32%; T4:24%) and T2-­negative DCM (C6:35%; C8:54%; T4:26%).

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PhysiologySurgeryMedical Imaging

Determining anatomically-safe corridors for placement of lateral mass screws in the first cervical vertebra of the Emirati population – a CT study

Scientific Reports, 2025 • January 1, 2025

This study used CT scans of 160 Emirati patients to determine the optimal screw dimensions, entry points, bony corridors, and screw trajectories for C1 lateral mass screw placement. The research ident...

KEY FINDING: The study found that a screw entry at the center of the lateral mass, below its junction with the posterior arch, allowed straight screws of lengths 20 mm and 19.5 mm in Emirati males and females, respectively.

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Cardiovascular SciencePhysiologyMedical Imaging

Posterior Cerebral Circulation Insufficiency Due to Internal Carotid Artery Stenosis With an Atypical Vertebral Artery Originating From the Internal Carotid Artery Territory

Cureus, 2024 • December 18, 2024

The case report highlights a rare anatomical variation where the vertebral artery originates from the internal carotid artery, potentially leading to posterior circulation neurological deficits if the...

KEY FINDING: A dominant right vertebral artery was found to originate from the right internal carotid artery in a 76-year-old female.

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PhysiologyPain ManagementGenetics

NaHS modulates astrocytic EAAT2 expression to impact SNI-induced neuropathic pain and depressive-like behaviors

Scientific Reports, 2025 • January 14, 2025

This study investigates the therapeutic effect of NaHS on neuropathic pain using the spared nerve injury (SNI) model in mice, focusing on astrocytes and glutamate. The findings reveal that NaHS enhanc...

KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.

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PhysiologyNeurologyPain Management

Establishing an Electrophysiological Recording Platform for Epidural Spinal Cord Stimulation in Neuropathic Pain Rats

Journal of Pain Research, 2025 • January 21, 2025

The study comprehensively analyzed methodology and technical challenges and pitfalls encountered during the development and implementation of this model. We presented a reliable electrophysiological p...

KEY FINDING: SNI enhanced the C component of eLFPs in bilateral cortexes elicited by stimulating the contralateral but not the ipsilateral lateral aspect of the hind paw.

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PhysiologyHealthcareBiomedical

Roles and current applications of S-nitrosoglutathione in anti-infective biomaterials

Materials Today Bio, 2022 • September 2, 2022

The review summarizes the progress made in the applications of GSNO in anti-infective biomaterials. It mainly includes the biological properties of GSNO and its application in biomaterials and provid...

KEY FINDING: GSNO possesses antibacterial activity influenced by factors like bacterial strain, dose, treatment duration, and NO release kinetics. Studies have evaluated GSNO's antibacterial properties in pulmonary, cutaneous, and other infections.

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PhysiologyTrauma

Comparison of treatment recompression tables for neurologic decompression illness in swine model

PLoS ONE, 2022 • October 5, 2022

This study compared four recompression treatment tables (TT6, TT6A-air, TT6A-nitrox, TT6A-heliox) for neurologic decompression illness (DCI) in a swine model. The primary outcome was the mean number o...

KEY FINDING: No significant differences were found in functional neurologic outcomes among the four treatment groups (TT6, TT6A-air, TT6A-nitrox, and TT6A-heliox) or between the two treatment profiles (TT6 and TT6A).

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Spinal Cord InjuryImmunologyPhysiology

An insight into new glycotherapeutics in glial inflammation: Understanding the role of glycosylation in mitochondrial function and acute to the chronic phases of inflammation

CNS Neurosci Ther, 2023 • January 1, 2023

This study investigates the modulation of glycans in glial cells during neuroinflammation associated with spinal cord injury (SCI) using a mixed glial culture model. The researchers used lectin microa...

KEY FINDING: Differential glycosylation occurs in glial cells during the transition from acute to chronic inflammation in a mixed glial culture model induced by cytokines.

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PhysiologyNeurologySurgery

The Role of Magnetic Transcranial Stimulation in the Diagnosis and Post-Surgical Follow-Up of Cervical Spondylotic Myelopathy

Int. J. Environ. Res. Public Health, 2023 • February 19, 2023

This retrospective study evaluated the role of TMS and SSEP in the diagnosis and post-surgical follow-up of DCM patients. Twenty-four patients undergoing surgical decompression were assessed using neu...

KEY FINDING: Post-operative TMS and SSEP results did not correlate with clinical outcomes at six months.

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PulmonologyPhysiologyBioinformatics

Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis

Nature Communications, 2023 • May 26, 2023

This study uses spatial metabolomics to understand the biology of pulmonary fibrosis (PF) by identifying a potential role for glycogen utilization during fibrosis disease progression. The researchers ...

KEY FINDING: High-dimensionality reduction and spatial clustering (HDR-SC) of MALDI-MSI datasets can accurately identify tissue microanatomy in both healthy and diseased lung tissues.

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