Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 501-510 of 639 results
Cells, 2024 • March 24, 2024
The advance of nanotechnologies for the treatment of refractory spinal cord pathologies requires an in-depth understanding of neurobiological and topographical principles and a consideration of additi...
KEY FINDING: Nanoparticle size, shape, and surface chemistry are critical factors influencing their interaction with biological systems, affecting drug delivery and cellular uptake in SCI treatment.
Cell Death Discovery, 2024 • April 24, 2024
This study investigates the therapeutic potential of salidroside in treating spinal cord injury (SCI). The research focuses on salidroside's impact on nerve regeneration, glial scar formation, astrocy...
KEY FINDING: Salidroside enhances functional recovery in SCI mice by promoting axonal regeneration, myelin reconstitution, and inhibiting glial scar formation and the activation of neurotoxic A1 astrocytes.
Regenerative Biomaterials, 2024 • April 10, 2024
This study investigates a multifunctional DSCM hydrogel incorporating curcumin and NT-3 for spinal cord injury (SCI) therapy, demonstrating enhanced NSCs proliferation and neuronal differentiation. Th...
KEY FINDING: The integration of both NT-3 and curcumin significantly enhanced NSCs proliferation and their neuronal differentiation.
Neurotherapeutics, 2024 • May 1, 2024
This study investigated the effects of selective PDE4B and PDE4D inhibitors on SCI pathology in mice. The PDE4D inhibitor Gebr32a improved functional and histopathological outcomes after SCI, similar ...
KEY FINDING: The PDE4D inhibitor Gebr32a improved functional recovery after SCI, even when administered 2 days post-injury.
Advanced Science, 2024 • October 16, 2024
This study introduces two novel ruthenium (II) half-sandwich complexes with diverse NˆN-chelating ligands for treating spinal cord injury (SCI). The complex Ru-EA demonstrates superior ROS scavenging ...
KEY FINDING: Replacing the 𝜂6-Arene in bz-PA with bz-EA dramatically boosts the ROS neutralizing ability and neuroprotective efficacy of the complexes.
ACS Omega, 2024 • May 23, 2024
This study introduces AttFPGNN-MAML, a novel architecture for few-shot molecular property prediction that addresses the low data problem by incorporating a hybrid feature representation and leveraging...
KEY FINDING: The AttFPGNN-MAML method outperformed other methods on three out of four tasks in the MoleculeNet dataset, demonstrating superior performance in few-shot learning settings.
Neural Regen Res, 2025 • March 1, 2025
Spinal cord injury (SCI) results in permanent neurological disability and poses significant physical, financial, and psychological challenges. The complexity of SCI pathophysiology necessitates explor...
KEY FINDING: The combination of melatonin and dexamethasone showed suitable neuroprotective activities by reducing neutrophil infiltration, cytokine levels, tissue damage, inducible nitric oxide synthase expression, and apoptosis in SCI-treated mice, and motor recovery was also ameliorated.
Bioeng Transl Med, 2024 • January 1, 2024
This study introduces a novel approach for spinal cord injury (SCI) repair using plant-derived exosomes (PEs) extracted from Lycium barbarum L., loaded with isoliquiritigenin (ISL) and integrated into...
KEY FINDING: PEs from L. barbarum L. possess anti-inflammatory and neuronal differentiation promotion capabilities, showing enhanced neural differentiation compared to exosomes from ectomesenchymal stem cells (EMSCs).
Cureus, 2024 • June 21, 2024
Organophosphates (OP) are widely used pesticides that can cause delayed neurotoxicity, a rare condition where neurological symptoms manifest weeks after initial exposure. This case report presents a 2...
KEY FINDING: A 28-year-old male developed delayed myelopathy five weeks after acute chlorpyrifos poisoning, presenting with lower limb weakness, abnormal gait, and sensory loss.
Smart Medicine, 2023 • January 1, 2023
This study introduces bFGF‐loaded GelMA microspheres with excellent biocompatibility and sustained drug release for spinal cord injury repair. The microspheres are prepared using microfluidic technolo...
KEY FINDING: bFGF-loaded GelMA microspheres significantly promoted the proliferation and differentiation of neural stem cells in vitro.