Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 421-430 of 639 results
Biomedicines, 2021 • July 8, 2021
This study evaluated the efficiency of a cationic, hyperbranched poly(amidoamine)s-based nanoparticle system to deliver tdTomato mRNA to primary human bone marrow stromal cells (hBMSC), human synovial...
KEY FINDING: Transfection efficiencies varied among the cell types tested (bCH 28.4% ± 22.87, rTDSPC 18.13% ± 12.07, hBMSC 18.23% ± 14.80, hSDSC 26.63% ± 8.81).
Neural Regeneration Research, 2022 • March 1, 2022
We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and...
KEY FINDING: BPC 157 counteracted bilateral clamping of the common carotid arteries-induced stroke, sustained brain neuronal damages were resolved in rats as well as disturbed memory, locomotion, and coordination.
Nanomedicine (Lond.), 2021 • August 17, 2021
Secondary injury after SCI offers a therapeutic window for pharmacological treatments to prevent progressive tissue damage and improve functional outcomes. Nanomaterial-based therapeutic strategies sh...
KEY FINDING: Nanomaterials can be used to deliver drugs that protect the blood-spinal cord barrier (BSCB), reducing permeability and preventing immune cell infiltration after SCI.
Pharmaceuticals, 2021 • August 12, 2021
This study investigates the chirality-dependent anti-inflammatory effects of glutathione (GSH) after spinal cord injury (SCI) in an animal model, comparing d-chiral glutathione (D-GSH) and l-chiral gl...
KEY FINDING: D-GSH significantly increased axon regrowth in rats after spinal cord injury compared to L-GSH treatment, suggesting a chirality-dependent regenerative effect.
Acta Pharmacologica Sinica, 2022 • January 1, 2022
This study investigated the role of metformin in myelin preservation and nerve regeneration in a rat model of spinal cord injury (SCI). The results showed that metformin administration improved locomo...
KEY FINDING: Metformin improves locomotor function in SCI rats, reducing neuronal apoptosis and promoting axon regeneration.
Cell Biosci, 2021 • January 1, 2021
This review summarizes current knowledge and challenges in targeted delivery of neurotrophic factors (NTFs) into the central nervous system (CNS), focusing on available approaches like stem cells, vir...
KEY FINDING: Stem cells, viral vectors, and biomaterials have shown promise in delivering NTFs to the CNS.
Neurochemical Research, 2022 • October 18, 2021
This study demonstrates that clemastine, a drug known to promote myelination, can enhance functional recovery in a rat model of spinal cord injury (SCI). The findings indicate that clemastine treatmen...
KEY FINDING: Clemastine treatment significantly improved motor function recovery in rats with SCI, as measured by BBB scoring, sloping board tests, and grid walking analysis.
Endocrine Connections, 2021 • October 22, 2021
This study investigates the evolutionary conservation and functional divergence of two homologous MC3Rs in the allotetraploid frog Xenopus laevis in vitro. The study clarified the interaction between ...
KEY FINDING: xlMRAP2.L/S enhances α-MSH-stimulated xlMC3Rs signaling and reduces their surface expression.
International Journal of Molecular Sciences, 2021 • November 7, 2021
This review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins. The most important clinical application of L...
KEY FINDING: UFH, LMWH, and synthetic pentasaccharides are used to prevent and cure thromboembolic events, but UFH is also a modulator of cell adhesion, migration, communication, proliferation, and differentiation.
Oxidative Medicine and Cellular Longevity, 2022 • January 7, 2022
The review comprehensively covers the role of oxidative stress, inflammation, and apoptosis in the pathophysiology of SCI. It emphasizes the interconnectedness of these pathways and the need for multi...
KEY FINDING: Polyphenols can modulate neuronal oxidative stress, neuroinflammatory, and extrinsic axonal dysregulated pathways in SCI.