Pharmacology Research

KEY FINDING: Chronic 5-HT pharmacotherapy increased the proportion of cells that responded to stimulation above the level of the lesion in both the HLSM cortex and the FLM cortex.

KEY FINDING: Nonsmokers with SCI experienced a reduction in mixed forms of pain following nicotine exposure.

KEY FINDING: Fluoxetine treatment markedly improved motor functions in rats after spinal cord injury, as evidenced by improved performance in behavioral tasks such as the Montoya staircase task and horizontal ladder.

KEY FINDING: Lactacystin, the first nonprotein neurotrophic natural product, exhibits neuritogenic activity and affects cell morphology and intracellular cAMP levels, impacting microtubule assembly and protein synthesis.

KEY FINDING: Patients receiving progesterone and vitamin D had significantly higher motor powers and sensory function after 6 months of therapy compared to the placebo group.

KEY FINDING: No significant changes were observed in neuropsychological scales for memory, attention, and mood following montelukast treatment.

KEY FINDING: Macrophages and PDGFRβ+ pericytes exhibit a closely related spatiotemporal distribution in the injury core after SCI.

KEY FINDING: Therapeutic concentrations of lithium increase neuronal excitability and network activity in human iPSC-derived cortical neurons.

KEY FINDING: SPF-FB treatment significantly enhanced neurobehavioral sensory and motor performance in sciatic nerve-injured rats.

KEY FINDING: HPL promotes efficient cell proliferation, making it suitable for manufacturing cell therapeutics within reasonable timeframes.