Current knowledge and challenges associated with targeted delivery of neurotrophic factors into the central nervous system: focus on available approaches

The review discusses recent advances in delivering neurotrophic factors (NTFs) to the central nervous system (CNS). It highlights the advantages and disadvantages of different delivery methods, including stem cells, viral vectors, and biomaterials. NTFs are important for the survival and function of neurons. Effective delivery of NTFs to the CNS can potentially treat neurodegenerative diseases. The review focuses on challenges associated with each delivery method, including immune response, tumor formation, and the ability to cross the blood-brain barrier.

• 1
  Stem cells, viral vectors, and biomaterials have shown promise in delivering NTFs to the CNS.
• 2
  Each delivery method has its own advantages and disadvantages, including concerns about immune response, tumor formation, and the ability to cross the blood-brain barrier.
• 3
  Combining different delivery methods, such as natural and synthetic biomaterials, may be more effective than using them alone.