Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury; a randomized, double-blind, placebo controlled study

This study investigated whether combining progesterone and vitamin D with standard treatment could improve recovery for patients with acute traumatic spinal cord injury (SCI). Patients received either progesterone and vitamin D, or a placebo, in addition to methylprednisolone. The researchers assessed motor and sensory function using the American Spinal Injury Association (ASIA) score at 6 days, 3 months, and 6 months after the injury. The study found that patients who received progesterone and vitamin D showed significantly greater improvements in motor and sensory functions after 6 months compared to those who received the placebo.

• 1
  Patients receiving progesterone and vitamin D had significantly higher motor powers and sensory function after 6 months of therapy compared to the placebo group.
• 2
  Those who received the therapy within 4 hours of injury had significantly higher motor powers and sensory function 6 months after treatment in the progesterone and vitamin D group.
• 3
  Therapy lag was negatively associated with 6-month motor powers and sensory function in the progesterone and vitamin D group, indicating that earlier treatment leads to better outcomes.