Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 371-380 of 639 results
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This retrospective study investigated the relationship between intrathecal baclofen (ITB) and autonomic dysreflexia (AD) in 34 patients with spinal cord injury (SCI). The study found a significant red...
KEY FINDING: A significant reduction in AD episodes was observed after ITB pump placement; 73.5% of subjects experienced AD prior to ITB, compared to only 5.9% after placement.
TheScientificWorldJOURNAL, 2006 • February 17, 2006
The objective of this article was to determine the current practice on amikacin dosing and monitoring in spinal cord injury patients from spinal cord physicians and experts. This study shows that ther...
KEY FINDING: Clinical practice varies considerably across spinal units regarding amikacin administration, with some using once-daily dosing and others using divided doses.
Molecular Pain, 2006 • April 3, 2006
The study investigated the role of PKC in spinal cord in mediating chronic injury-induced pain and its relationship with glutamate receptors. Activation of PKC in the spinal cord produces mechanical h...
KEY FINDING: Intrathecal injection of PDBu (phorbol 12,13 dibutyrate) decreased the mechanical withdrawal threshold bilaterally in a dose-dependent manner, indicating increased sensitivity to pain.
Spinal Cord Series and Cases, 2017 • May 11, 2017
This case report describes the successful use of ceftolozane/tazobactam (C/T) to treat a febrile urinary tract infection (UTI) caused by multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA) in a 35-...
KEY FINDING: Ceftolozane/tazobactam was effective in treating a febrile UTI caused by multidrug-resistant Pseudomonas aeruginosa in a patient with a neurogenic bladder.
Spinal Cord Series and Cases, 2017 • May 18, 2017
This correspondence critically evaluates a study comparing amitriptyline and lamotrigine for neuropathic pain after spinal cord injury. The authors highlight the scarcity of direct comparisons between...
KEY FINDING: The original study by Agarwal and Joshi reports the effectiveness of amitriptyline and lamotrigine in neuropathic pain after traumatic spinal cord injuries.
Spinal Cord Series and Cases, 2017 • June 8, 2017
This case report presents a 27-year-old male with a T10 ASIA Impairment Scale A spinal cord injury who developed hyperphosphatemia as a complication of etidronate therapy for heterotopic ossification....
KEY FINDING: A patient with SCI developed hyperphosphatemia during etidronate treatment for HO.
J Mol Neurosci, 2008 • November 1, 2008
Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are expressed in the neural pathways regulating the lower urinary tract. VIP-immunoreactivity (IR...
KEY FINDING: Exogenously applied VIP relaxes bladder and urethral smooth muscle and excites parasympathetic neurons in bladder ganglia.
Brain, 2010 • January 1, 2010
This study investigated the effects of long-term baclofen use on the contractile properties of paralyzed motor units in individuals with cervical spinal cord injury. The results indicated that baclofe...
KEY FINDING: Long-term baclofen use and paralysis resulted in significantly weaker motor unit tetanic forces compared to uninjured subjects.
CNS Neuroscience & Therapeutics, 2025 • January 17, 2025
Existing studies have shown that Sirt1 plays a core role in neuroprotection and tissue repair by regulating inflammatory response, oxidative stress, autophagy, and mitochondrial function. Sirt1 can me...
KEY FINDING: Sirt1 exerts broad regulatory effects across diverse pathological processes and cell types post-SCI. It promotes neuronal survival and axonal regeneration, modulates astrocytes and microglia to resolve inflammation, supports oligodendrocyte-mediated myelination, and enhances vascular endothelial function.
Arch Phys Med Rehabil, 2010 • May 1, 2010
This review supports the use of anticonvulsants such as gabapentin or pregabalin for post-SCI neuropathic pain. Tricyclic antidepressants were supported by limited evidence in those patients with supe...
KEY FINDING: Gabapentin and pregabalin, anticonvulsant medications, have strong evidence for effectiveness in treating neuropathic pain post-SCI.