Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 361-370 of 639 results
PLoS ONE, 2016 • January 20, 2016
This study aimed to understand the opinions of SCI patients regarding MPSS treatment for acute SCI, given the controversy surrounding its use. A summary of MPSS literature was created and reviewed by ...
KEY FINDING: The majority of SCI patients felt that small neurological benefits from MPSS were 'very important' to them.
The Journal of Spinal Cord Medicine, 2018 • January 1, 2018
This case report describes the successful use of droxidopa in a patient with a spinal cord injury who had refractory orthostatic hypotension (OH) that was not responding to standard treatments. The pa...
KEY FINDING: Droxidopa increased blood pressure levels in the patient, specifically a 10 mm Hg increase in systolic BP and 6 mm Hg in diastolic BP in the supine position.
Glia, 2016 • June 1, 2016
This study investigates the protective effects of adrenergic receptor agonists, specifically epinephrine (EPI) and isoprenaline (ISO), on cellular edema induced by hypotonicity and neurotrauma in cort...
KEY FINDING: Epinephrine administration reduces hypotonicity-induced swelling of astrocytes both in vivo and in vitro.
International Journal of Rehabilitation Research, 2017 • January 24, 2017
This pilot study aimed to develop a treatment diary for patients receiving botulinum toxin injections and physiotherapy for spasticity. The diary focused on problems caused by muscle overactivity, tre...
KEY FINDING: Patients found the treatment diary helpful in becoming more involved in their treatment.
Annals of Rehabilitation Medicine, 2011 • October 1, 2011
This study investigated the impact of spinal cord injury (SCI) on colonic contractility and muscarinic receptor subtypes in rats. The researchers aimed to determine how SCI-induced changes in M2 and M...
KEY FINDING: SCI rats showed an increased response to Ach in the proximal colon compared to control rats, indicating altered contractility after SCI.
Top Spinal Cord Inj Rehabil, 2016 • January 1, 2016
This cross-sectional study investigates the characteristics of individuals with chronic SCI who use cannabis for therapeutic purposes (CTP) and examines their reasons for use, SCI-related complication...
KEY FINDING: A significant percentage of individuals with chronic SCI use CTP regularly, with pain being the most common reason.
Medicine, 2019 • September 1, 2019
This network meta-analysis protocol outlines the methods for assessing the efficacy and safety of different doses of azilsartan medoxomil in patients with hypertension. The study will search multiple ...
KEY FINDING: This study will summarize all available data to provide reliable evidence of the value of different doses of azilsartan medoxomil for hypertension treatment.
Clinical Pharmacology in Drug Development, 2021 • March 1, 2021
This study reports the first clinical experience with MW189, a novel CNS-penetrant small molecule that selectively suppresses injury- and disease-induced glial proinflammatory cytokine overproduction....
KEY FINDING: MW189 was safe and well tolerated in single and multiple doses up to 0.25 mg/kg, with infusion-site reactions being the most common adverse event.
Drug Design, Development and Therapy, 2020 • December 4, 2020
This study investigates the effect of sanguinarine (SG) on chronic constriction injury (CCI)-induced neuropathic pain (NP) in rats. SG is a natural plant medicine known for its anti-inflammatory and n...
KEY FINDING: Sanguinarine (SG) treatment increased paw withdrawal mechanical threshold (PWT) and thermal withdrawal latency (TWL) in CCI rats, indicating reduced mechanical sensitivity and heat hypersensitivity.
Eur Spine J, 2004 • August 14, 2003
This technical note presents a minimally invasive technique using topical rt-PA for evacuating extensive spinal subdural haematomas in two patients on long-term anticoagulation therapy. The technique ...
KEY FINDING: Topical application of rt-PA allows evacuation of the haematoma through a limited surgical exposure.