Pharmacology Research

KEY FINDING: The review was withdrawn due to being substantially out-of-date.

KEY FINDING: Following oral administration of SSRI in an individual with motor incomplete SCI there are notable alterations in clinical measures of motor activity.

KEY FINDING: Substantial differences exist among SCI centers in the indications for UTI treatment, medications used, and treatment duration, often deviating from existing guidelines.

KEY FINDING: AMPH combined with skilled forelimb motor training improved qualitative reaching in rats with cervical SCI compared to controls and drug-only groups.

KEY FINDING: Baclofen is considered a first-line treatment for spasticity, especially in adult spinal cord injuries, acting as a GABAB agonist to reduce muscle excitability.

KEY FINDING: One RCT provided Level 1 evidence that GM-1 ganglioside in combination with physical therapy improved motor scores, walking velocity and distance better than placebo and physical therapy in persons with incomplete SCI.

KEY FINDING: HBO therapy and psychotherapy both significantly reduced depression (HAMD scores) compared to the control group.

KEY FINDING: Transdermal administration of neostigmine/glycopyrrolate by iontophoresis appears to be a practical, safe, and effective approach to induce bowel evacuation in individuals with spinal cord injury.

KEY FINDING: The combination of methylprednisolone and G-CSF promoted greater functional improvement than methylprednisolone or G-CSF alone.

KEY FINDING: There is urgent need to develop disease-modifying therapy for SCI, yet the commercial landscape remains small and highly fragmented with a paucity of novel late-stage compounds in R&D.