Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 11-20 of 639 results
Drug Discov Today, 2012 • September 1, 2012
This review discusses advances in non-viral gene delivery for spinal cord injury (SCI) treatment. Non-viral vectors offer a safer alternative to viral vectors, with higher DNA-carrying capacity and th...
KEY FINDING: Non-viral gene vectors can transfect endogenous cells in the injured spinal cord, leading to the production of therapeutic molecules and long-lasting biological effects.
Neurotherapeutics, 2012 • August 31, 2012
This study investigates the therapeutic potential of the sigma-1R agonist PRE-084 in the SOD1G93A mouse model of ALS. The results demonstrate that PRE-084 administration significantly improves motor n...
KEY FINDING: PRE-084 administration from 8 weeks of age improved the function of MNs, which was manifested by maintenance of the amplitude of muscle action potentials and locomotor behavior, and preserved neuromuscular connections and MNs in the spinal cord.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2011 • June 6, 2011
The study investigated the neuroprotective effects of erythropoietin (EPO) on spinal cord injury (SCI) in rats, focusing on the role of platelet-derived growth factor (PDGF)-B. Results showed that EPO...
KEY FINDING: EPO treatment resulted in a more rapid recovery in SCI rats, as evidenced by higher BBB scores.
British Journal of Pharmacology, 2013 • February 1, 2013
This study investigates the effects of denosomin on functional recovery in SCI mice and elucidates the mechanism through which denosomin induces axonal growth in the injured spinal cord. The key findi...
KEY FINDING: Denosomin improves motor dysfunction and axonal growth, especially in 5-HT-positive tracts across the scar, and increases astrocyte density in SCI mice.
PLoS ONE, 2012 • November 20, 2012
This study combined computational and biochemical methods to identify small molecule inhibitors of PTPs. The in silico docking showed that the identified compounds are molecularly accommodated by the ...
KEY FINDING: Several compounds were identified that inhibit PTPs activity in vitro with micromolar potency.
Adv Funct Mater, 2010 • May 10, 2010
This study developed nanofibrous scaffolds with aligned nanofibers for nerve guidance and drug delivery in spinal cord. The scaffolds with rolipram increased axon growth through the scaffolds and in t...
KEY FINDING: Scaffolds with rolipram significantly improved hindlimb function after 3 weeks in rats with spinal cord injury.
ACS Chem Biol., 2013 • May 17, 2013
The study developed a high-content analysis (HCA) screening bioassay using primary mammalian neurons to identify small-molecule PKIs that can promote neurite growth. Screening a library of 240 PKIs re...
KEY FINDING: A robust cell-based assay with a Z′-factor of 0.73 was developed, indicating high reliability and suitability for medium throughput screening.
Biomatter, 2011 • October 1, 2011
Chondroitin sulfate is a major component of the extracellular matrix in both the central and peripheral nervous systems. Interestingly, the novel chondroitin sulfate-binding peptide enhances the contr...
KEY FINDING: PEG gels that contained only C6S (PEG-C6S) had the fastest NGF release, while gels that contained both BP and C6S had the slowest release profile (PEG-BP-C6S).
Neurosci Bull, 2013 • August 1, 2013
After spinal cord injury (SCi), re-establishing functional circuitry in the damaged central nervous system (CNS) faces multiple challenges including lost tissue volume, insufficient intrinsic growth c...
KEY FINDING: Combinatorial therapies with ChABC have shown synergistic effects with cell implantation in enhancing functional recovery after spinal cord injury, improving graft integration and axon regeneration across the lesion.
Journal of Pharmacology and Pharmacotherapeutics, 2013 • July 1, 2013
The study introduces a cost-effective customized impact device for creating experimental spinal cord injuries in rats, addressing the financial limitations faced by researchers in developing countries...
KEY FINDING: The customized impact device produced consistent lesion effects in rats, as evaluated by behavioral scoring methods.