Browse the latest research summaries in the field of pharmacology for spinal cord injury patients and caregivers.
Showing 211-220 of 639 results
Proteins: Structure, Function, and Bioinformatics, 2025 • January 1, 2025
This study demonstrates that valacyclovir and acyclovir, commonly used antiviral drugs, are substrates of the enzyme cypin, which deaminates these compounds. The research uses NADH-coupled assays, try...
KEY FINDING: Valacyclovir and acyclovir are deaminated by cypin, meaning cypin breaks them down.
Journal of Extracellular Biology, 2022 • December 1, 2022
The study introduces a novel drug delivery platform technology, BioDrone™, based on cell-derived vesicles (CDVs) produced from diverse cell sources using a proprietary extrusion process. Physical, bio...
KEY FINDING: Extrusion technology generates nanosized vesicles in far greater numbers than naturally obtained EVs.
International Journal of Immunopathology and Pharmacology, 2018 • August 28, 2018
Glial scar formation is a complex response to injury in the central nervous system, involving astrocytes, immune cells, and extracellular matrix deposition, which can both inhibit and promote neural r...
KEY FINDING: Glial scar formation involves the activation of resident astrocytes, which surround the lesion core and wall off intact neurons in neurological damages.
Biomaterials, 2012 • January 1, 2012
This study explores the use of glycomimetic-functionalized collagen as a biomaterial for neural tissue engineering. Type I collagen scaffolds were functionalized with peptide mimics of polysialic acid...
KEY FINDING: Grafted HNK-1 encouraged motor neuron outgrowth, but not sensory neuron outgrowth, maintaining modality-specific responses.
Chembiochem, 2020 • April 1, 2020
This study demonstrates the ability of OleD Loki to glycosylate a diverse set of HDAC inhibitors, forming hydroxamate glycosyl esters. The resulting glycosylated products exhibited reduced cytotoxicit...
KEY FINDING: OleD Loki can convert a wide range of HDAC inhibitors into their corresponding hydroxamate glycosyl esters.
Dev Dyn, 2021 • June 1, 2021
This study investigates the effects of CoCl2, a chemical that induces hypoxia and cellular stress, on axolotl tail regeneration, particularly in the context of romidepsin-induced regeneration inhibiti...
KEY FINDING: CoCl2 can partially rescue the inhibitory effect of romidepsin on tail regeneration when co-administered for 1 minute post-amputation (MPA).
Frontiers in Pharmacology, 2021 • July 20, 2021
bFGF is involved in all stages of pulp repair/regeneration and uses different intracellular signaling pathways to control specific biological processes, which may be determined by cell origins and trea...
KEY FINDING: bFGF acts through binding to tyrosine kinase FGF receptors on the cell membrane, triggering intracellular signaling pathways that initiate cell migration, proliferation, and differentiation.
Frontiers in Pharmacology, 2021 • May 18, 2021
The study investigated the adverse effects of chronic sulfasalazine (SAS) treatment in mice, focusing on whether these effects are related to the inhibition of system xc−. Two different doses of SAS w...
KEY FINDING: SAS had a negative impact on the survival rate of mice of both genotypes, independent of its inhibitory action on system xc−.
Frontiers in Pharmacology, 2024 • September 13, 2024
Boldine is an orally active alkaloid with good tolerability in rodents, showing efficacy across various animal models of disease or injury. Open connexin hemichannels (CxHC) are consistently found in ...
KEY FINDING: Boldine blocks connexin (Cx) hemichannels (HCs), and many of its effects in rodent models are attributed to this blockade.
Nanoscale Advances, 2024 • September 15, 2024
The study successfully developed a micellar thermosensitive hydrogel (MCPP-M-gel) encapsulating minocycline (MC) using PEG–PLGA copolymer for spinal cord injury (SCI) treatment. In vitro, MCPP-M-gel e...
KEY FINDING: MCPP-M-gel demonstrated favorable physico-mechanical properties and extended MC release over 72 hours in vitro without cytotoxic effects on neural crest-derived ectoderm mesenchymal stem cells (EMSCs).