Serotonin (5-HT)2A/2C receptor agonist 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride improves detrusor sphincter dyssynergia by inhibiting L-type voltage-gated calcium channels in spinal cord injured rats

This study investigates how a specific drug, 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride, affects bladder control in rats with spinal cord injuries. It focuses on a condition called detrusor sphincter dyssynergia (DSD), where the bladder and the muscle controlling urine flow don't coordinate properly. The researchers found that the drug improves DSD by influencing calcium channels, specifically L-type voltage-gated calcium channels, in the spinal cord. These channels play a role in muscle control and nerve signaling. By blocking these calcium channels, the drug helps to restore the coordinated relaxation of the muscle controlling urine flow, which is impaired in rats with spinal cord injuries.

• 1
  Intrathecal administration of 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride or nifedipine increased voiding volume and enhanced voiding efficiency in rats with SCI.
• 2
  2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride and nifedipine increased the number of high-frequency oscillations (HFOs) in SCI rats, suggesting that they enhance urethral function.
• 3
  The effect of 2,5-dimethoxy-4-iodophenyl-2-aminopropane hydrochloride in improving SCI-induced DSD was eliminated with the combined administration of L-type VGCC agonist, (±)-Bay K 8644.