Muscle Nerve, 2011 · DOI: 10.1002/mus.22115 · Published: October 1, 2011
This research investigates the genetic factors that might make some people more likely to experience muscle problems (myopathy) when taking statins, a common type of cholesterol-lowering drug. The study found that certain variations in the EYS gene, which is important for eye function and also found in the spinal cord, are linked to a higher risk of developing severe myopathy from statins. This suggests that EYS may have a role in maintaining and repairing muscle tissue, and that people with these genetic variations might have a reduced capacity for muscle regeneration when taking statins.
Identifying individuals at risk for statin-induced myopathy based on genetic susceptibility may allow for the development of pharmacogenetic approaches to disease prevention.
The finding that EYS, a gene previously known for its role in eye function, is also expressed in the spinal cord and may play a role in muscle regeneration opens new avenues for research into muscle biology.
Genetic screening for EYS variants could potentially help clinicians personalize statin therapy, choosing alternative treatments or adjusting dosages for individuals at higher risk of myopathy.