VEGF and FGF-2 delivery from spinal cord bridges to enhance angiogenesis following injury

J Biomed Mater Res A, 2011 · DOI: 10.1002/jbm.a.33112 · Published: September 1, 2011

Spinal Cord Injury Pharmacology Biomedical

Simple Explanation

This research investigates using spinal cord bridges that release VEGF and FGF-2 to promote blood vessel and nerve growth after spinal cord injury. The bridges were made from a biodegradable material (PLG) and loaded with the proteins in different ways to control how quickly they are released. The study found that bridges releasing these proteins increased blood vessel formation and nerve fiber presence within the injury site, suggesting a potential way to improve spinal cord regeneration.

Study Duration

6 weeks

Participants

Thirty four female Long-Evans rats

Evidence Level

Not specified

Key Findings

1
Encapsulation of proteins within microspheres resulted in slower protein release compared to mixing proteins directly into the bridge material.
2
VEGF was released more rapidly than FGF-2 from the bridges, regardless of the incorporation method.
3
Bridges releasing VEGF and FGF-2 increased the infiltration of endothelial cells and formation of blood vessels at 6 weeks post implantation.

Research Summary

The study investigates the use of PLG bridges to deliver VEGF and FGF-2 to promote angiogenesis and nerve growth after spinal cord injury. The method of protein incorporation affects release, with encapsulation leading to slower release than direct mixing. VEGF/FGF-2 releasing bridges increased blood vessel formation and endothelial cell infiltration, suggesting a potential approach to enhance spinal cord regeneration.

Practical Implications

Promoting Angiogenesis

Localized delivery of angiogenic factors can enhance blood vessel formation in the injured spinal cord, addressing ischemia.

Controlled Drug Delivery

PLG bridges can provide a sustained and controlled release of therapeutic proteins to the injury site.

Stabilizing the Injury Site

Bridge implantation provides mechanical support, prevents cavity formation, and supports cell infiltration, contributing to spinal cord regeneration.

Study Limitations

1
Pore structure may need optimization to fully support blood vessel ingrowth.
2
Relationship between VEGF dosage and morphology/function of new blood vessels needs further investigation.
3
Further research is required to optimize the time frame and doses of protein release.

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