Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 441-450 of 682 results
Molecular Pain, 2023 • January 1, 2023
This study investigates the mechanisms underlying dynamic allodynia, a type of neuropathic pain, in a spared nerve injury (SNI) mouse model. The findings demonstrate that SNI-induced dynamic allodynia...
KEY FINDING: Downregulation of neuronal membrane KCC2 (mKCC2) in the spinal dorsal horn of SNI mice is closely associated with SNI-induced dynamic allodynia.
J Comp Neurol, 2016 • February 1, 2016
We examined whether there were changes in the number of different types of synapses during the development of chronic orofacial pain after CCI-ION. Our data indicate that trigeminal nerve injury leads...
KEY FINDING: Trigeminal nerve injury leads to an increase in R-synaptic profiles (presumably excitatory synapses) in lamina I of Vc/C2.
Toxins, 2015 • July 10, 2015
This study demonstrated that repetitive injections of DBV into the Joksamli acupuncture point during the induction phase (one to five days after SCI) of below-level neuropathic pain significantly prod...
KEY FINDING: Repetitive DBV stimulation during the induction period suppressed pain behavior in the ipsilateral hind paw.
Scientific Reports, 2016 • December 20, 2016
This study investigates the crosstalk between activated microglia and neurons in the spinal dorsal horn and its contribution to stress-induced hyperalgesia using a rat model combining single-prolonged...
KEY FINDING: The study found that stress combined with inflammation (using Complete Freund’s Adjuvant) significantly increased pain sensitivity (mechanical allodynia) in rats.
PM R, 2014 • August 1, 2014
This study examined the relationship between pain location and its impact on functioning in individuals with spinal cord injury (SCI) and chronic pain. The research aimed to determine if pain site and...
KEY FINDING: Pain extent and intensity are positively associated with pain interference (r = 0.33, P < .01), indicating that greater pain extent and intensity lead to more significant interference with daily activities.
The Journal of Spinal Cord Medicine, 2014 • January 1, 2014
This study evaluated the effectiveness of rTMS for treating intractable neuropathic pain in SCI patients. Seventeen participants were randomized into real and sham rTMS groups and received ten daily s...
KEY FINDING: Both real and sham rTMS significantly reduced pain scores (VAS) in patients with SCI and neuropathic pain.
JOURNAL OF NEUROTRAUMA, 2016 • July 15, 2016
The study investigated the relationship between neuropathic pain symptoms, pain severity, and N-acetylaspartate (NAA) levels in brain areas involved in pain processing among individuals with subacute ...
KEY FINDING: Subjects with Moderate Neuropathic Pain had significantly lower insular NAA than the Low or no Neuropathic Pain group.
Neurorehabil Neural Repair, 2016 • August 1, 2016
The study determined if delaying exercise intervention until pain is detected would similarly ameliorate established SCI-induced pain. The results show that delaying exercise until allodynia develops ...
KEY FINDING: Exercise therapy initiated at early stages of allodynia is ineffective at attenuating neuropathic pain.
The Journal of Spinal Cord Medicine, 2017 • May 1, 2017
A consensus-building workshop in 2006 aimed to develop a research agenda for SCI-related chronic pain, involving 39 stakeholders and using a modified Delphi approach to identify top research prioritie...
KEY FINDING: The top five pain research priorities identified were pain management and treatment, measurement tools, health services policy and advocacy, knowledge transfer, and mechanisms of pain.
The Journal of Spinal Cord Medicine, 2017 • May 1, 2017
The study explored the relationship between pain and mood during spinal cord injury rehabilitation, finding significant correlations between the two. Improvements in pain were associated with improvem...
KEY FINDING: Significant improvements were observed in both pain and mood from the initial assessment (NAC1) to the pre-discharge assessment (NAC2).