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  4. The effect of repetitive transcranial magnetic stimulation on refractory neuropathic pain in spinal cord injury

The effect of repetitive transcranial magnetic stimulation on refractory neuropathic pain in spinal cord injury

The Journal of Spinal Cord Medicine, 2014 · DOI: 10.1179/2045772313Y.0000000172 · Published: January 1, 2014

Spinal Cord InjuryNeurologyPain Management

Simple Explanation

This study investigates if a non-invasive brain stimulation technique, repetitive transcranial magnetic stimulation (rTMS), can reduce chronic nerve pain in patients with spinal cord injuries (SCI). rTMS uses magnetic pulses to alter brain activity. The study compared real rTMS to a sham treatment. Patients received ten daily sessions of either real or sham rTMS, and their pain levels were assessed at baseline, 10 days, 6 weeks, and 6 months after treatment. The results showed both real and sham rTMS reduced pain. However, the pain relief wasn't significantly different between the two groups, suggesting the benefit might be due to a placebo effect. The researchers suggest further studies with more patients.

Study Duration
Approximately 21 Months
Participants
17 patients with SCI and chronic neuropathic pain
Evidence Level
Level I: Prospective, randomized, double-blinded, controlled study

Key Findings

  • 1
    Both real and sham rTMS significantly reduced pain scores (VAS) in patients with SCI and neuropathic pain.
  • 2
    The real rTMS group showed significant pain reduction at 10 days and 6 weeks compared to baseline, while the sham group only showed a significant reduction at 10 days.
  • 3
    There was no significant difference between the real and sham rTMS groups in terms of pain scores or patient satisfaction at any assessment point.

Research Summary

This study evaluated the effectiveness of rTMS for treating intractable neuropathic pain in SCI patients. Seventeen participants were randomized into real and sham rTMS groups and received ten daily sessions. Pain was assessed using VAS scores at baseline, 10 days, 6 weeks, and 6 months. Both groups experienced a significant reduction in pain, but no statistically significant difference was found between the groups at any assessment point. The study concludes that rTMS was not superior to placebo in treating neuropathic pain in SCI patients. However, the middle-term pain relief suggests a need for future studies with a larger sample size.

Practical Implications

Limited Clinical Benefit

rTMS may not provide a significant advantage over placebo for treating neuropathic pain in SCI patients in a clinical setting.

Need for Further Research

Larger studies are warranted to investigate the potential of rTMS for mid-term pain relief in SCI patients with neuropathic pain.

Sham Contol Considerations

Future studies should consider using more reliable and valid sham controls, such as recently developed sham coils, to account for sensory aspects of stimulation.

Study Limitations

  • 1
    Small sample size
  • 2
    Lack of navigation for rTMS
  • 3
    The type of sham used

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