Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 351-360 of 682 results
The Journal of Spinal Cord Medicine, 2020 • July 1, 2020
This case report demonstrates that dry needling treatment can have positive effects on spasticity, dynamic stability, walking velocity, self-independence, and pain in patients with incomplete spinal c...
KEY FINDING: Dry needling immediately reduced spasticity in both upper and lower limbs, as measured by the modified Ashworth Scale.
Neuromodulation, 2021 • April 1, 2021
The study explored the effects of central neuromodulation on autonomic function and pain in SCI+NP and AB cohorts. Active BreEStim led to analgesia and increased parasympathetic tone in SCI+NP individ...
KEY FINDING: SCI+NP persons demonstrated increased parasympathetic tone (increased NN50, p=0.03, and pNN50, p=0.02, HRV parameters) following active BreEStim only.
Pain Practice, 2020 • January 1, 2020
This study investigates the role of GABAergic mechanisms in the analgesic effects of burst and tonic spinal cord stimulation (SCS) in a rat model of chronic neuropathic pain induced by partial sciatic...
KEY FINDING: Burst SCS significantly lowers intracellular GABA levels in the spinal dorsal horn compared to sham SCS and tonic SCS.
A A Pract, 2019 • December 1, 2019
This case report describes the successful use of spinal cord stimulation (SCS) to treat chronic neuropathic pain in a patient with idiopathic transverse myelitis (TM). The patient experienced signific...
KEY FINDING: A 37-year-old male with idiopathic TM and chronic neuropathic pain experienced 70% pain improvement during a SCS trial.
Nature Communications, 2019 • September 13, 2019
This study identifies circAnks1a as a key regulator in neuropathic pain, showing its expression is increased following nerve injury in a rodent model. Reducing circAnks1a levels alleviates pain-like b...
KEY FINDING: Spinal nerve ligation increases circAnks1a expression in dorsal horn neurons.
The Journal of Spinal Cord Medicine, 2019 • January 1, 2019
This study evaluated the effectiveness of the Spinal Cord Injury Knowledge Mobilization Network (SCI KMN) implementation approach in improving pain management practices for inpatients with spinal cord...
KEY FINDING: Provider adherence for most outcomes exceeded 70% completion within acceptable timeframes, with improvements found for all outcomes as compared to the retrospective cohort.
Spinal Cord Series and Cases, 2019 • September 1, 2019
This randomized, double-blinded, placebo-controlled, crossover study explored the effectiveness of botulinum toxin A (BoNTA) for treating at-level spinal cord injury (SCI) pain. Although the data did ...
KEY FINDING: A higher proportion of participants reported a marked change in average pain intensity from baseline to 8 and 12 weeks post-BoNTA vs. post-placebo (33% vs. 0%).
J. Clin. Med., 2023 • December 23, 2022
The study assessed TSPO expression as an indicator of microglial activation using (R)-[11C]PK11195 PET imaging in a rat SCI model. Clinical application of (R)-[11C]PK11195 PET/MRI in patients with NeP...
KEY FINDING: TSPO is mainly expressed in activated microglia in the injured spinal cord.
Scientific Reports, 2019 • October 15, 2019
This study investigated the roles of activated microglia and infiltrating macrophages in neuropathic pain (NeP) associated with chronic progressive spinal cord compression using a mouse model. The mai...
KEY FINDING: The severity of spinal cord compression correlated with the proportion of activated microglia and hematogenous macrophages in the spinal cord.
Journal of NeuroEngineering and Rehabilitation, 2019 • September 6, 2019
This study investigated the usability and effectiveness of a home-based, self-managed brain-computer interface (BCI) neurofeedback (NFB) system for treating central neuropathic pain (CNP) in individua...
KEY FINDING: Twelve participants regulated their brainwaves in a frequency specific manner and were most successful upregulating the alpha band power.