Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 311-320 of 682 results
Neural Plasticity, 2021 • October 21, 2021
The analgesic mechanisms of SCS are gradually unveiled with the involvement of the “Gate control” theory, segmental inhibition, the descending inhibitory system, and cortical modulation. It is recomme...
KEY FINDING: SCS modulates nociceptive processing by inhibiting ascending nociceptive transmission via GABA and endocannabinoids, facilitating descending inhibition by releasing noradrenalin, dopamine, and serotonin, and activating supraspinal brain areas related to pain perception and emotion.
JRM-CC, 2021 • August 26, 2021
SAC are rare lesions that may present with a constellation of neurological symptoms: paraesthesia, neuropathic pain, paresis and gait disturbances, just like a (progressive) spinal cord injury due to ...
KEY FINDING: Spinal arachnoid cysts may present with a heterogeneous clinical picture.
Neurotrauma Reports, 2021 • January 1, 2021
This study investigated the role of microRNAs (miRNAs) in neuropathic pain following spinal cord injury (SCI) by screening miRNA expression in plasma samples from individuals with and without SCI. The...
KEY FINDING: 383 miRNAs were differentially expressed in acute or chronic SCI versus no SCI.
Frontiers in Pain Research, 2022 • July 28, 2022
This review explores the emerging evidence for intrathecal management of neuropathic pain following spinal cord injury (SCI). It highlights the challenges in treating neuropathic pain in SCI patients ...
KEY FINDING: Neuropathic pain after SCI involves complex mechanisms including neuronal excitability, glial dysregulation, and chronic inflammation.
Brain Sci., 2021 • October 28, 2021
This study investigated the effects of whole-body extremely low-frequency electromagnetic field (EMF) stimulation on nociception and sensorimotor deficits in rats with complete thoracic spinal cord in...
KEY FINDING: EMF stimulation significantly attenuated hyperalgesia and allodynia to thermal, electrical, and chemical stimuli from 6 weeks onwards in rats with complete SCI.
Frontiers in Medicine, 2021 • November 24, 2021
This systematic review and expert consensus evaluated the effectiveness and efficacy of exercise for neuropathic pain (NP) across various diseases. The study aimed to provide evidence-based exercise r...
KEY FINDING: Exercise is helpful to alleviate NP intensity, recommending it as an effective alternative or complementary therapy.
Redox Biology, 2022 • January 1, 2022
This study investigates the role of Dynamin-related protein 1 (Drp1), a key regulator of mitochondrial fission, in neuropathic pain (NP) using a spared nerve injury (SNI) model in mice. The research f...
KEY FINDING: SNI in mice induces pain behavior and anxiety-like behavior, which is associated with elevation of Drp1, as well as increased density of mitochondria in SDH.
Medicine, 2021 • December 2, 2021
The case report describes a 46-year-old woman with chronic low back pain and chronic pelvic pain (CPP) following multiple pelvic fractures, who experienced significant pain relief and improved quality...
KEY FINDING: Two weeks after the intervention a reduction of 80% of the pain was achieved, which led to the removal of the pharmacologic treatment.
Molecular Pain, 2022 • January 1, 2022
The study evaluated the effect of differential target multiplexed programming (DTMP) spinal cord stimulation (SCS) on proteins involved in ion transport regulation in the spinal cord of rats with neur...
KEY FINDING: DTMP modulated a larger number of proteins involved in ion transport regulation compared to LR SCS.
Spinal Cord, 2022 • February 1, 2022
Adults with traumatic SCI are at increased risk for developing both general psychological morbidity as well as most specific psychological conditions. Chronic centralized and neuropathic pain is robus...
KEY FINDING: Adults with SCI had a higher incidence of psychological morbidities compared to those without SCI.