Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 301-310 of 682 results
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This scoping review examined the existing research on the effect of cannabis on pain intensity in individuals with spinal cord injury (SCI). The review found that the current evidence is insufficient ...
KEY FINDING: The review identified six articles covering five treatment studies, but the findings were mixed due to variations in methodology.
Cureus, 2021 • June 1, 2021
This case report describes a rare instance of spinal cord injury (SCI) following thoracic radiofrequency ablation (RFA). The patient, a 37-year-old male, developed paresthesias, weakness, and urinary ...
KEY FINDING: The patient experienced paresthesias below the nipple line and progressive lower-extremity weakness within one week of the procedure.
The Journal of Spinal Cord Medicine, 2023 • January 1, 2023
This study investigated the efficacy of FES cycling for pain reduction in patients with SCI. The results showed significant improvements in pain scores, quality of life, and neurophysiological measure...
KEY FINDING: Statistically significant changes were found in pain-NRS, MPI-SCI, and SF-36 scores, and LEP amplitudes, indicating a reduction in pain and improved quality of life following FES cycling.
Current Neuropharmacology, 2022 • January 1, 2022
This review summarizes current knowledge about four epigenetic modifications—DNA/RNA methylation, histone acetylation, and circRNAs—in chronic pain. Epigenetic modifications may shed lights on the chr...
KEY FINDING: DNA methylation, mediated by enzymes like DNMTs and TETs, plays a role in chronic pain development. Specifically, the upregulation of methyltransferase DNMT3a is widely involved in chronic pain induced by a variety of causes, and it promotes the occurrence and development of chronic pain by inhibiting the transcription of analgesic-related genes by increasing the methylation level of these genes.
International Journal of Environmental Research and Public Health, 2021 • August 25, 2021
This pilot study investigated the immediate effect of VR in reducing neuropathic pain (NP) in people with spinal cord injury (SCI). Eight individuals with chronic NP after SCI underwent consecutive ex...
KEY FINDING: Short-term exposure to both scenery and somatic VR environments resulted in a significant reduction in neuropathic pain intensity in people with spinal cord injury.
BIOENGINEERED, 2021 • August 4, 2021
This study investigates the role of circSMEK1 in neuropathic pain (NP) using rat and cell models. The results indicate that circSMEK1 and TXNIP are upregulated in NP, while miR-216a-5p is downregulate...
KEY FINDING: CircSMEK1 and TXNIP are upregulated in neuropathic pain (NP), while miR-216a-5p is downregulated.
Brain Sciences, 2021 • September 12, 2021
Neuropathic pain following spinal cord injuries is difficult to treat. VR offers an alternative by providing illusory or reality-like experiences. VR modulates body ownership and agency, increasing pa...
KEY FINDING: VR can modulate the sense of ownership of the whole body or single body parts by altering the congruity of multisensory information.
BMJ Case Reports, 2021 • September 15, 2021
Intrathecal baclofen is recognised as an effective treatment option for severe symptoms of segmental spasticity after spinal cord injury. We suggest an effective bridging and weaning protocol for oral...
KEY FINDING: Sudden removal of an intrathecal baclofen pump can lead to severe withdrawal symptoms, including increased spasticity, pain, and seizures.
Frontiers in Pharmacology, 2021 • September 13, 2021
This study investigates the effects of long-term nimodipine (NMD) administration on functional recovery in rats with spinal cord injury (SCI). The results indicate that NMD improves locomotor function...
KEY FINDING: Long-term NMD administration improves locomotor function in rats with SCI without affecting hind limb grip strength.
The Journal of Spinal Cord Medicine, 2022 • January 1, 2022
This pilot study assessed the feasibility and potential benefits of a Clinical Meditation and Imagery (CMI) intervention for people with chronic pain after spinal cord injury (SCI). The study found th...
KEY FINDING: Pain interference decreased more in the control group, contrary to the initial hypothesis.