Pain Management Research

KEY FINDING: Most studies used inbred, young adult, male mice with peripheral nerve injury, limiting the generalizability of the data.

KEY FINDING: Patients with CEI had significantly better long-term pain reduction after DREZotomy compared to those with SCI.

KEY FINDING: NDSM demonstrates significant analgesic effects against chronic pain in both pain-evoked and pain-suppressed behavioral assays.

KEY FINDING: SCI decreased 7,8-DHF-induced current while increasing the latency to its peak amplitude.

KEY FINDING: Comp 6d alleviates neuropathic pain by specifically activating SIRT1 in the spinal cord, as demonstrated by the abolishment of its effects in SIRT1 knockout mice.

KEY FINDING: The study found unique spatial atlases of genes, cell populations, cell-cell cross-talks, signaling pathways, and transcriptional regulatory networks in the spinal cord of neuropathic pain mice compared to sham mice.

KEY FINDING: In an animal model of neuropathic pain, application of capsaicin or RTX to adjacent uninjured nerves completely alleviated and prevented mechanical and thermal hyperalgesia following L5 nerve injury.

KEY FINDING: SNI induces chronic pain and depressive-like behaviors in mice, evidenced by decreased mechanical pain threshold, thermal pain latency, and reduced exploratory behavior.

KEY FINDING: SCS produced a significant consistent and sustained improvement in pain intensity by 49% in DN4 and 76% in VAS.

KEY FINDING: Efgartigimod, an FcRn blocker, alleviated mechanical allodynia when administered either 7 or 28 days post-CCI.