Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 181-190 of 682 results
Frontiers in Pharmacology, 2024 • March 21, 2024
This study explores the analgesic effects of α2-adrenoceptor activation, particularly by dexmedetomidine (DEX), in the spinal cord, focusing on its molecular mechanisms. It utilizes behavioral, transc...
KEY FINDING: Spinal nerve injury changes the spinal transcriptome expression, with differential genes mainly related to calcium signaling and tissue metabolic pathways.
Brain, Behavior, & Immunity - Health, 2024 • March 30, 2024
This study examines the role of myelin basic protein (MBP) fragments in inducing neuropathic pain, with a specific focus on the sex-specific effects of MBP84-104. The research demonstrates that MBP84-...
KEY FINDING: MBP84-104 interacts with and inactivates LXRα, a nuclear transcription factor that regulates cholesterol metabolism and inflammation.
Brain and Spine, 2024 • March 14, 2024
Spinal cord stimulation (SCS) is a widespread treatment for chronic neuropathic pain originating from different causes, particularly failed back surgery syndrome (FBSS) and complex regional pain syndr...
KEY FINDING: Proper patient selection is crucial for achieving the best outcomes with spinal cord stimulation for neuropathic pain.
Drug Design, Development and Therapy, 2024 • April 18, 2024
This study explores the potential analgesic properties of obacunone (OB) in a CFA-induced inflammatory pain (IP) model in mice. The findings suggest that OB treatment facilitates a shift in microglia ...
KEY FINDING: OB treatment decreased PWF, paw thickness, M1 phenotype marker iNOS, CD86 significantly, while PWL, M2 phenotype marker Arg-1, IL-10, Nrf2, HO-1 increased significantly.
Asian J Neurosurg, 2024 • February 26, 2024
This case report describes the successful use of retrograde epidural spinal cord stimulation (SCS) in a patient with intractable neuropathic pain caused by spinal cord and cauda equina injuries and ex...
KEY FINDING: Retrograde epidural SCS is a feasible option for patients with extensive epidural fibrosis or aberrant vertebral anatomy.
Turkish Journal of Medical Sciences, 2023 • December 12, 2023
This study aimed to explore the therapeutic effects of ginger extract, enriched with trans-[6]-shogaol and [6]-gingerol, on neuroinflammation in the spinal cord and cortex of rats with experimental sc...
KEY FINDING: Ginger treatment significantly improved locomotor activity and reduced thermal hyperalgesia in CCI rats, indicating a positive impact on pain-related behaviors.
International Journal of Medical Sciences, 2024 • May 13, 2024
This study investigated the effects of pregabalin on microglial differentiation in a rat model of neuropathic pain induced by sciatic nerve damage. The rats were treated with either pregabalin or a co...
KEY FINDING: Pregabalin treatment significantly reduced neuronal damage in both the brain and spinal cord of neuropathic pain rats compared to the control group.
Molecular Therapy: Nucleic Acids, 2024 • June 1, 2024
This study investigates the role of neurexin 2 in cancer-induced bone pain (CIBP), finding that its expression is increased in the spinal dorsal horn (SDH) of CIBP rats and correlates with pain hypers...
KEY FINDING: Neurexin 2 expression is significantly increased in the spinal dorsal horn (SDH) of rats with cancer-induced bone pain (CIBP), and this increase is correlated with lower pain thresholds.
Bioinformation, 2024 • April 30, 2024
The study evaluated the efficacy of gabapentin, pregabalin, and amitriptyline in treating neuropathic pain. 270 patients were divided into three groups, each receiving one of the medications, and thei...
KEY FINDING: Gabapentin, pregabalin, and amitriptyline demonstrate similar effectiveness in alleviating neuropathic (NeP) pain.
Journal of Neuroimmune Pharmacology, 2024 • June 15, 2024
This study investigated the impact of minocycline on individual differences in pain-related affective disturbances in nerve-injured rats using a naturalistic foraging paradigm. The research focused on...
KEY FINDING: Minocycline completely prevented the emergence of an 'affected' subgroup of rats displaying disrupted foraging behaviours after nerve injury.