Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 171-180 of 682 results
bioRxiv preprint, 2024 • February 18, 2024
The study investigates the short and long-term effects of mouse serum-derived sEVs on pain modulation. sEVs from both naïve control and SNI model donor mice were found to transiently increase basal me...
KEY FINDING: Mouse serum-derived sEVs transiently increased basal mechanical thresholds in recipient mice, an effect mediated by opioid signaling.
Journal of Neuroinflammation, 2024 • February 16, 2024
This study investigates the role of cerebrospinal fluid (CSF) in the dissemination of neuropathic pain, leading to widespread pain symptoms. The key finding is that interleukin-6 (IL-6) in the CSF of ...
KEY FINDING: CCI-ION induced local pain in vibrissa pads together with widespread pain in hind paws.
Frontiers in Neurology, 2024 • February 14, 2024
This study evaluated the efficacy of cranial electrotherapy stimulation (CES) combined with transcutaneous electrical nerve stimulation (TENS) for burning mouth syndrome (BMS). The study found that bo...
KEY FINDING: Both active and sham CES groups showed a significant decrease in pain intensity over the study period.
Top Spinal Cord Inj Rehabil, 2024 • January 1, 2024
This study investigated the frequency of prescription opioid use among individuals with SCI and its relationship with demographic, injury, and socioeconomic characteristics. The study found that a sig...
KEY FINDING: 47.1% of participants with SCI used at least one prescription opioid in the past year.
Int. J. Mol. Sci., 2024 • March 1, 2024
The study examined the therapeutic effect of EPA on fibromyalgia pain and its cellular mechanisms in a mouse model, using intermittent cold stress to induce fibromyalgia. EPA administration reversed m...
KEY FINDING: EPA attenuated mechanical and thermal hyperalgesia in mice with fibromyalgia.
Journal of Pain Research, 2024 • March 11, 2024
This scoping review examines the potential of psychedelics in managing chronic pain, focusing on conditions like cluster headache, phantom limb pain, and fibromyalgia. The review includes nine studies...
KEY FINDING: Several studies suggest that psychedelics, particularly psilocybin and LSD, may reduce pain symptoms in chronic pain conditions such as phantom limb pain and cluster headaches.
Journal of Pain Research, 2024 • March 13, 2024
This study investigated thermo-nociceptive processing in individuals with CRPS type I using contact-heat evoked potentials (CHEPs) and quantitative sensory testing (QST). The key finding was that indi...
KEY FINDING: CHEP amplitudes were increased in individuals with CRPS compared to healthy controls after stimulation of the painful limb.
PLoS ONE, 2024 • March 20, 2024
This study evaluated the therapeutic potential of maropitant in treating neuropathic pain in rats by assessing its effects on oxidative stress, endoplasmic reticulum stress, and neuroinflammation in t...
KEY FINDING: Maropitant inhibited nociception with an ID50 value of 4.1 mg/kg in a neuropathic pain model induced by chronic constriction injury (CCI).
Anesth Analg, 2024 • November 1, 2024
This study investigates the role of spinal neuroplastin 65 (NP65) in neuropathic pain (NP) by examining its regulatory effect on the gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2). The hypo...
KEY FINDING: The expression level of NP65 protein and mRNA were significantly decreased in the CCI group compared to the control group, indicating a downregulation of NP65 in neuropathic pain conditions.
Indian Journal of Orthopaedics, 2024 • February 19, 2024
This study evaluated the effects of Low-Level Laser Therapy (LLLT) on pain and disability in patients with Failed Back Surgery Syndrome (FBSS). The study included 50 patients with FBSS who received LL...
KEY FINDING: LLLT significantly improved NRS and ODI scores in FBSS patients after treatment.