Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 161-170 of 682 results
The Journal of Neuroscience, 2024 • January 24, 2024
This study unveils that KCC2 controls spinal nociceptive synaptic strength via NMDA receptors in a cell type- and synapse type-specific manner. Spinal KCC2 impairment triggers pain hypersensitivity thr...
KEY FINDING: KCC2 inhibition preferentially augments presynaptic and postsynaptic NMDA receptor activity in spinal excitatory interneurons via α2δ-1.
Nat Rev Dis Primers, 2023 • August 17, 2023
Central neuropathic pain (CNP) arises from lesions or diseases affecting the central somatosensory nervous system, with conditions like spinal cord injury and stroke being common causes. The underlyin...
KEY FINDING: Central post-stroke pain (CPSP) is the most prevalent form of central neuropathic pain worldwide, given the high number of new stroke cases each year.
Frontiers in Pharmacology, 2023 • December 11, 2023
This study investigates the phase-specific effects of progesterone on neuropathic pain in mice with sciatic nerve injury, focusing on the roles of P450c17 and 5α-reductase. The research reveals that p...
KEY FINDING: Intrathecal progesterone administration during the induction phase of chronic pain enhanced mechanical allodynia development and spinal GFAP expression, an effect inhibited by a P450c17 inhibitor.
Front. Pain Res., 2023 • December 21, 2023
This study explored the self-reported effects of cannabis and cannabinoids on neuropathic pain and pain medication use in individuals with spinal cord injury (SCI). The findings suggest that cannabis ...
KEY FINDING: 87.9% of participants reported that cannabis reduced their neuropathic pain intensity by more than 30%.
PLOS ONE, 2024 • January 16, 2024
This study evaluated the effects of different analgesic regimens on the well-being and functional outcomes of rats with spinal cord injuries (SCI). Forty-two female Wistar rats were divided into six g...
KEY FINDING: Analgesia improved animal well-being, as indicated by body weight, Rat Grimace Scale (RGS) scores, and dark-phase home cage activity.
Neurotrauma Reports, 2024 • January 1, 2024
The study compared functional connectivity in SCI patients with moderate-severe chronic neuropathic pain to SCI patients with mild-no neuropathic pain and control subjects using resting-state fMRI. Re...
KEY FINDING: Specific thalamic nuclei (medial pulvinar, lateral pulvinar, medial geniculate nucleus, lateral geniculate nucleus, and mediodorsal magnocellular nucleus) showed altered functional connectivity in SCI patients with moderate-to-severe neuropathic pain compared to those with mild-to-no pain.
Cell Reports, 2024 • February 27, 2024
Microglia are implicated as primarily detrimental in pain models; however, they exist across a continuum of states that contribute to homeostasis or pathology depending on timing and context. Unexpect...
KEY FINDING: Microglia depletion and repopulation at the acute-to-chronic transition completely resolved pain and improved peripheral inflammation.
Molecular Pain, 2024 • January 23, 2024
This study aimed to investigate the anti-nociceptive effect of PD1 and investigate its molecular mechanism involving neuro-inflammatory processes. Our findings strongly suggest that PD1 exerts its analg...
KEY FINDING: PD1 significantly reversed the NCLDH-induced imbalance in neuro-inflammatory response and alleviated the symptoms of mechanical and thermal hyperalgesia.
Med Arch, 2023 • October 4, 2023
This systematic review and meta-analysis evaluated the use of spinal cord stimulation (SCS) for chronic pain management following traumatic brachial plexus injuries. The review included 13 studies (8 ...
KEY FINDING: 86% of patients showed a good initial response to SCS, but the response decreased over time.
eNeuro, 2024 • February 1, 2024
This study investigates the potential of cypin inhibition as a therapeutic approach for SCI-induced neuropathic pain using the small molecule inhibitor B9 in a mouse model. The key finding is that B9 ...
KEY FINDING: B9 alleviates mechanical pain after SCI. Intrathecal administration of B9, starting at 1 day postinjury (dpi) until 7 dpi, attenuates mechanical pain in hindlimbs at 3 weeks pi.