Pain Management Research

KEY FINDING: Oral COR167 attenuated mechanical allodynia and thermal hyperalgesia in a dose-dependent manner after acute and repeated administration, without tolerance induction.

KEY FINDING: Emodin elevated response latency and delayed the onset of mechanical hyperalgesia in rats with CCI on days 7, 14, and 21.

KEY FINDING: Repeated opioid treatment reduces mGluR5 protein levels in the DRG but increases them in the spinal cord, suggesting trafficking from DRG to spinal cord.

KEY FINDING: Nerve injury induces a change in PVIN firing patterns from tonic to adaptive in male mice.

KEY FINDING: Autophagy flow is blocked in the spinal dorsal horn of mice with chronic constriction injury (CCI), indicating impaired cellular cleaning processes during neuropathic pain.

KEY FINDING: PBM therapy improves neuropathic pain behaviors after spinal cord injury in rats.

KEY FINDING: A single dose of mirogabalin is more effective than pregabalin in reducing tactile hypersensitivity in mice with nerve injury.

KEY FINDING: Systemic administration of ICI-204448 and asimadoline reduced below-level pain hypersensitivity in SCI mice. However, high-dose asimadoline adversely affected the exploratory performance of SCI mice and caused aversion.

KEY FINDING: Multiple intradural SACs are rare, with only six cases being reported in the literature, including the one hereby presented.

KEY FINDING: Both pramipexole and dexpramipexole significantly reduced allodynia in mice within one hour of intravenous injection, although the effect was temporary, with allodynia returning after 24 hours.