Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 111-120 of 682 results
Frontiers in Molecular Neuroscience, 2023 • April 21, 2023
This review summarizes existing clinical trials on neuropathic pain (NP) treatment to provide insights into potential novel therapeutic strategies, including drug targets, new uses for conventional me...
KEY FINDING: The study identified several potential novel drug targets for different types of neuropathic pain, including BDKRB1, HDAC6, and NMDAR, which are being explored in ongoing clinical trials.
Cells, 2023 • April 27, 2023
The study investigates the therapeutic effects of simultaneously inhibiting AEA hydrolysis and oxygenation in treating neuropathic pain using a chronic constriction injury (CCI) mouse model. The combi...
KEY FINDING: The FAAH inhibitor PF04457845 and the substrate-selective COX-2 inhibitor LM4131 dose-dependently reduced thermal hyperalgesia and mechanical allodynia in the CCI mice.
Pharmaceutical Biology, 2023 • January 1, 2023
The study investigates the analgesic effects of daphnetin on neuropathic pain (NP) in rats with chronic constriction injury (CCI). Daphnetin treatment improved pain thresholds, reduced inflammatory ma...
KEY FINDING: Daphnetin improved thermal and mechanical withdrawal thresholds in rats with neuropathic pain, indicating reduced pain sensitivity.
The Journal of Neuroscience, 2023 • May 24, 2023
This study demonstrates, for the first time, that chemotherapy and traumatic nerve injury preferentially enhance the NMDAR activity at primary afferent–excitatory neuron synapses but have no effect on...
KEY FINDING: Paclitaxel treatment or spared nerve injury (SNI) similarly increased the NMDAR-mediated mEPSC frequency and dorsal root-evoked EPSCs in VGluT2 dorsal horn neurons.
Front. Hum. Neurosci., 2023 • May 2, 2023
This study explored nociceptive withdrawal reflexes in individuals with SCI using radiant heat laser stimuli, revealing hyperreflexia and the involvement of both A-delta and C-fibers. The findings ind...
KEY FINDING: Individuals with SCI showed a significantly higher percentage of responses, response rates, and reflex magnitude to noxious heat compared to non-disabled controls, indicating hyperresponsiveness.
J Pain, 2023 • October 1, 2023
This study investigated the effect of voluntary running exercise on nociceptive sensitization and endogenous pain control systems in a rodent model of mild closed-head TBI. The main observations were ...
KEY FINDING: Exercise reduced hindpaw and periorbital allodynia (pain from non-painful stimuli) after TBI, indicating a decrease in pain sensitivity.
Molecular Pain, 2023 • January 1, 2023
This study investigates the preventive and therapeutic effects of a sub-anesthetic dose of propofol on chronic post-ischemic pain (CPIP) in mice, a model for complex regional pain syndrome (CRPS). The...
KEY FINDING: Propofol attenuates mechanical allodynia induced by CPIP in mice, both when administered pre-emptively and post-operatively.
The Journal of Spinal Cord Medicine, 2023 • July 1, 2023
This study assessed high-risk opioid prescription metrics among individuals with chronic SCI, including chronic use, high-dose therapy, and concurrent BSH use. The findings indicate a concerning numbe...
KEY FINDING: Over half (53%) of the individuals filled an opioid prescription in years 2–3 after injury.
bioRxiv preprint, 2023 • June 9, 2023
This study demonstrates that astrocyte SOCE is necessary and sufficient for central sensitization and the development of hypersensitivity in Drosophila. The research adds new understanding to the astr...
KEY FINDING: Astrocytes exhibit SOCE-dependent calcium signaling three to four days after nerve injury in a Drosophila model.
PLOS ONE, 2023 • June 22, 2023
This study evaluated the effects of oral MaR1 treatment on neuropathic pain (NP) and spinal neuroinflammation in mice with spared nerve injury (SNI). MaR1 reduced mechanical hypersensitivity, potentia...
KEY FINDING: Oral MaR1 treatment reduced SNI-induced mechanical hypersensitivity in both male and female mice on days 7 and 11 post-surgery.