Browse the latest research summaries in the field of pain management for spinal cord injury patients and caregivers.
Showing 131-140 of 682 results
Anesthesiology, 2023 • December 1, 2023
The study characterized the neurochemical and electrophysiological phenotype of Oprm1-INs in the murine dorsal horn, revealing their contribution to neuropathic pain-like behavior. Peripheral nerve in...
KEY FINDING: Spared nerve injury (SNI) reduces Oprm1 gene expression and the responsiveness of Oprm1-INs to DAMGO, a selective μ agonist.
Cellular & Molecular Biology Letters, 2023 • September 7, 2023
This study investigates the role of astrocyte senescence in neuroinflammation and neuropathic pain (NeP) following peripheral nerve injury (PNI). The findings suggest that PNI induces a senescence-lik...
KEY FINDING: Sciatic nerve CCI in rats resulted in reduced paw mechanical withdrawal threshold (PMWT) and paw thermal withdrawal latency (PTWL), indicating pain hypersensitivity.
Journal of Translational Medicine, 2023 • August 2, 2023
Sciatic nerve crush led to motor dysfunction, reduction in exploration behavior, and a robust increase in mechanical and thermal hypersensitivity that were found to be mediated by neuroinflammation, n...
KEY FINDING: HBOT alleviates mechanical and thermal hypersensitivity and motor dysfunction following sciatic nerve crush (SNC).
FEBS Open Bio, 2023 • January 1, 2023
This study identified a significant increase in SOCE-mediated calcium influx following injury-induced neuropathic pain. Pharmacologically inhibition of SOCE by both SKF96365 and YM-58483 had an analge...
KEY FINDING: SOCE-mediated calcium influx was significantly increased following nerve injury in neuropathic rats.
Pflügers Archiv - European Journal of Physiology, 2023 • August 25, 2023
This study assessed the reliability of electrical stimulation to measure detection and pain thresholds in the skin and muscles of the lower back, comparing these measurements to established quantitati...
KEY FINDING: Excellent intra-session reliability was observed for cutaneous and intramuscular electrical stimulations.
Pharmaceuticals, 2023 • July 28, 2023
This study evaluated the effectiveness of THC, CBD, and a combination of THC&CBD in capsule form for treating neuropathic pain and spasticity in patients with multiple sclerosis or spinal cord injury....
KEY FINDING: No significant difference was found between the THC, CBD, or THC&CBD groups and the placebo group in reducing mean pain intensity.
Journal of Orthopaedic Surgery and Research, 2023 • September 28, 2023
The study aimed to elucidate the mechanism of action of DHJSD on NP by identifying and analyzing active components, target genes and related signaling pathways, and validating the results in a CCI rat...
KEY FINDING: DHJSD treatment repaired the CCI-induced inflammatory reaction in the spinal cord while regulating the expression of ACHE, NOS2, MAPK3, PTGS2, AKT1, and PPARG mRNA.
bioRxiv preprint, 2023 • August 14, 2023
This study investigates the contribution of RVM serotonergic neurons to pain processing in the spinal trigeminal nucleus caudalis (SpVc) in acute and chronic pain models in mice. The findings suggest ...
KEY FINDING: Optogenetic activation of RVM serotonergic afferents in the spinal cord produces mechanical hypersensitivity and conditioned place aversion in naïve mice.
Cochrane Database of Systematic Reviews, 2023 • August 1, 2023
This review included 32 studies with 4924 participants to evaluate the efficacy of remotely-delivered psychological interventions for chronic pain in adults. The most common remotely-delivered psychol...
KEY FINDING: Remotely-delivered CBT shows small benefits for pain intensity and functional disability in adults experiencing chronic pain.
Journal of Traditional Chinese Medicine, 2023 • August 2, 2023
The study evaluated the effects of berberine on morphine analgesia, tolerance, and hyperalgesia in mice, utilizing acute, chronic, and established morphine tolerance models. The researchers measured p...
KEY FINDING: Berberine can prolong the duration of morphine analgesia.