Pain Management Research

KEY FINDING: Satellite glial cells (SGCs) and astrocytes, while sharing critical functions, are not entirely congruent in their responses to nerve injury and activate on different timescales. SGCs become active rapidly (hours to days), while astrocytes in the dorsal horn show changes after days to weeks.

KEY FINDING: Δ9-THC levels were higher in mice receiving the THC-rich extract compared to pure THC, suggesting improved bioavailability from the extract.

KEY FINDING: SWELL1-dependent VRAC directly conducts and releases ATP from cells.

KEY FINDING: Paeonol decreases M1 markers (IL1β, iNOS, CD32, IL6) and increases M2 markers (IL10, CD206, ARG-1) in LPS-induced microglia.

KEY FINDING: TWL threshold decreased and nNOS expression increased in CCI and DEX groups compared to the sham group after the operation.

KEY FINDING: BoNTs inhibit the release of neurotransmitters involved in the pain pathway, including CGRP, glutamate, substance P, and ATP, by suppressing SNARE proteins.

KEY FINDING: Pregabalin significantly reduced pain intensity in patients with diabetes mellitus, after stroke, with lower back pain, and with multiple sclerosis.

KEY FINDING: DTMP reversed expression levels of 83% of proteins affected by the pain model back to levels seen in uninjured animals, whereas a low-rate (LR-SCS) approach reversed 67%.

KEY FINDING: 5-HT can either promote or inhibit pain depending on neural circuits, such as spinal pathways. It can also have excitatory or inhibitory functions in the same brain regions, depending on its receptors.

KEY FINDING: Peripheral nerve injury downregulates ciRNA-Kat6b in the dorsal spinal horn of male mice, and rescuing this downregulation alleviates CCI-induced pain hypersensitivities.