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  4. Regulation of Expression of Extracellular Matrix Proteins by Differential Target Multiplexed Spinal Cord Stimulation (SCS) and Traditional Low-Rate SCS in a Rat Nerve Injury Model

Regulation of Expression of Extracellular Matrix Proteins by Differential Target Multiplexed Spinal Cord Stimulation (SCS) and Traditional Low-Rate SCS in a Rat Nerve Injury Model

Biology, 2023 · DOI: 10.3390/biology12040537 · Published: March 31, 2023

NeurologyPain ManagementGenetics

Simple Explanation

The extracellular matrix comprises an important collection of proteins that aids in the body’s response to pain. Of the 186 proteins identified as extracellular-matrix-related, DTMP reversed expression levels of 83% of them back to levels seen in uninjured animals, whereas LR-SCS reversed 67%. Relative to the pain model, DTMP had a reversal effect on 76% versus 58% by LR-SCS on phosphorylated proteins.

Study Duration
Not specified
Participants
Male Sprague-Dawley rats (n = 10 per group)
Evidence Level
Not specified

Key Findings

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    DTMP reversed expression levels of 83% of proteins affected by the pain model back to levels seen in uninjured animals, whereas a low-rate (LR-SCS) approach reversed 67%.
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    DTMP back-regulated 76% of phosphoproteins affected by the pain model back toward levels found in uninjured animals, whereas LR-SCS back-regulated 58%.
  • 3
    The proteomic analysis identified 7192 proteins in the excised spinal cord tissue of these animals.

Research Summary

This study evaluates the matrisome following induction of the SNI pain model using proteomic analyses. Additionally, we studied the effectiveness of SCS using either DTMP or a conventional low-rate SCS (LR-SCS) program in reversing changes to the ECM induced by the pain model. Phosphorylation changes of matrisome proteins were also evaluated, as phosphorylation can lead to the activation or inactivation of pathways that are not likely to produce significant protein expression changes of their non-phosphorylated state.

Practical Implications

Improved Understanding of Pain Pathways

The study expands knowledge of ECM-related proteins responding to a neuropathic pain model.

Mechanism of Action of SCS Therapy

The research provides a better perspective on the mechanism of action of SCS therapy, particularly DTMP.

Guidance for Patient Care

The data provides valuable insights into the mechanism behind spinal cord stimulation therapies and can help better guide patient care.

Study Limitations

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