Orthopedics Research

KEY FINDING: BGs enhance osteogenic differentiation of precursor cells in vitro when added to CaPs, suggesting a synergistic effect.

KEY FINDING: Both zonal and non-zonal constructs showed a significantly increased bone loss in the defects when compared to controls, suggesting an osteolytic effect of PCL-enforced implants on the subchondral bone.

KEY FINDING: PEMF exposure of Il-1β-treated 3D tendon-like constructs resulted in a change in the expression pattern of approximately 5400 genes.

KEY FINDING: Patient age significantly correlates with the expression of MMP-2 and RUNX2 genes in the subscapularis tendon.

KEY FINDING: Age, tumor size, grade, and AJCC T staging were independent prognostic factors for OS and CSS.

KEY FINDING: Six miRNAs (hsa-miR-19b-3p, hsa-miR-192-5p, hsa-miR-25-3p, hsa-miR-19a-3p, hsa-miR-18b-5p, hsa-miR-93-5p) were exclusively repressed in patients with degenerative RCTs compared to controls and chronic tendinopathy.

KEY FINDING: The patient could walk and had no pain three months post-surgery.

KEY FINDING: Co-culturing nucleus pulposus cells (NPCs) and bone marrow-derived mesenchymal stem cells (BMSCs) in UPAL gel significantly increased the expression of NPC markers, growth factors, and extracellular matrix genes compared to monocultures.

KEY FINDING: miR-152 expression is significantly lower in cartilage tissue from OA patients and in chondrocytes treated with IL-1b, suggesting its involvement in OA progression.

KEY FINDING: UPAL gel implantation suppressed TNF-α and IL-6 production in both rat and rabbit models of discectomy.